2-氨基-3-溴-5-甲基苯甲酸合成路线 （共 8 条）
反应条件
bromine in acetic acid T=20°C; Bromination; 3 h;
参考文献
Clews, John; Curtis, Anthony D.M.; Malkin, Hugh
Tetrahedron, 2000 , vol. 56, # 44 p. 8735 - 8746
反应条件
lithium hydroxide hydrate in tetrahydrofuran T=20°C;
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 21, # 4 p. 1270 - 1274
参考文献
Ghisalberti, Emilio L.; Jefferies, Phillip R.; Mori, Trevor A.; Skelton, Brian W.; White, Allan H.; Whiteside, Nola J.
Journal of Chemical Research, Miniprint, 1993 , # 12 p. 3155 - 3172
反应条件
1: 75 percent / H2SO4 2: 65 percent / H2O2 View Scheme
参考文献
Journal of Chemical Research, Miniprint, , # 12 p. 3155 - 3172
反应条件
hypophosphorous ether 1) diazotization; Multistep reaction;
参考文献
Ghisalberti, Emilio L.; Jefferies, Phillip R.; Mori, Trevor A.; Skelton, Brian W.; White, Allan H.; Whiteside, Nola J.
Journal of Chemical Research, Miniprint, 1993 , # 12 p. 3155 - 3172
反应条件
0.0666667 h; Neat (no solvent);
参考文献
Bristol-Myers Squibb Company
Patent: US2009/18163 A1, 2009 ;
Location in patent: Page/Page column 46 ;
US 20090018163 A1
反应条件
1: 2) hypophosphorus acid / 1) diazotization 2: p-toluenesulfonamide, PCl5 / 200 - 205 °C View Scheme
参考文献
Fisher; Dershem; Prewitt
Journal of Organic Chemistry, 1990 , vol. 55, # 3 p. 1040 - 1043
反应条件
in toluene
T=60°C; Cyclization;
参考文献
Clews, John; Curtis, Anthony D.M.; Malkin, Hugh
Tetrahedron, 2000 , vol. 56, # 44 p. 8735 - 8746
