(1S,4r)-4-氨基-2-环戊烯羧酸盐酸盐合成路线 （共 5 条）
参考文献
BioCryst Pharmaceuticals, Inc.
Patent: US6562861 B1, 2003 ;
反应条件
hydrogenchloride in ethanol
参考文献
Forro, Eniko; Fueloep, Ferenc
European Journal of Organic Chemistry, 2008 , # 31 p. 5263 - 5268
参考文献
BioCryst Pharmaceuticals, Inc.
Patent: US6562861 B1, 2003 ;
反应条件
1: conc. HCl / methanol / 20 h / Ambient temperature 2: pyridine / CH2Cl2 / 24 h / Ambient temperature 3: 73 percent / calcium chloride, sodium borohydride / tetrahydrofuran / 3 h / 40 °C / sonication 4: 2 M hydrochloric acid / ethanol / 48 h / Heating View Scheme
参考文献
Evans, Chris T.; Roberts, Stanley M.; Shoberu, Karoline A.; Sutherland, Alan G.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1992 , # 5 p. 589 - 592
反应条件
1: (1S,4R)-(-)-4-Aminocyclopent-2-en-1-carboxylic Acid Hydrochloride With N-ethyl-N,N-diisopropylamine in 1,4-dioxane; water T=0°C; 0.0833333 h; 2: di-tert-butyl dicarbonate in 1,4-dioxane; water T=0 - 20°C;
参考文献
ABBOTT LABORATORIES
Patent: US2009/312338 A1, 2009 ;
Location in patent: Page/Page column 68 ;
