6-甲基-1(2H)-异喹啉酮合成路线 （共 4 条）
反应条件
oxygen; Trimethylene glycol; copper(l) chloride; palladium dichloride in ethylene glycol dimethyl ether
参考文献
Izumi, Taeko; Nishimoto, Yasuhiro; Kohei, Kunihiro; Kasahara, Akira
Journal of Heterocyclic Chemistry, 1990 , vol. 27, # 5 p. 1419 - 1424
反应条件
1: 75 percent / tri-o-tolylphosphine, Et3N / Pd(II) acetate / acetonitrile / 24 h / 120 °C / 22800 Torr 2: 90 percent / O2, 1,3-propanediol / PdCl2, CuCl / 1,2-dimethoxy-ethane View Scheme
参考文献
Izumi, Taeko; Nishimoto, Yasuhiro; Kohei, Kunihiro; Kasahara, Akira
Journal of Heterocyclic Chemistry, 1990 , vol. 27, # 5 p. 1419 - 1424
反应条件
trichlorophosphate 3 h; Heating / reflux;
参考文献
BRISTOL-MYERS SQUIBB COMPANY
Patent: WO2003/99274 A1, 2003 ;
Location in patent: Page 292-293 ;
WO 03/099274 A1
反应条件
potassium hydroxide in dichloromethane
参考文献
Aventis Pharma Deutschland GmbH
Patent: US6281227 B1, 2001 ;
