1.1: thionyl chloride / dichloromethane / 3 h / 20 °C / Inert atmosphere 2.1: n-butyllithium; n-butyl-magnesium bromide / hexane; tetrahydrofuran / 0 °C 2.2: 5 h / -78 °C / Inert atmosphere 3.1: 4-(N,N-dimethlyamino)pyridine; triethylamine; hydrogen / palladium 10 on activated carbon / tetrahydrofuran / 24 h / 20 °C 4.1: triethylamine; 2-hydroxy-pyridine / tert-butyl methyl ether / 18 h / 80 °C 5.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C 5.2: pH 10 View Scheme

1.1: thionyl chloride / dichloromethane / 3 h / 20 °C / Inert atmosphere 2.1: n-butyllithium; n-butyl-magnesium bromide / hexane; tetrahydrofuran / 0 °C 2.2: 5 h / -78 °C / Inert atmosphere 3.1: 4-(N,N-dimethlyamino)pyridine; triethylamine; hydrogen / palladium 10 on activated carbon / tetrahydrofuran / 24 h / 20 °C 4.1: triethylamine; 2-hydroxy-pyridine / tert-butyl methyl ether / 18 h / 80 °C View Scheme

1.1: thionyl chloride / dichloromethane / 3 h / 20 °C / Inert atmosphere 2.1: n-butyllithium; n-butyl-magnesium bromide / hexane; tetrahydrofuran / 0 °C 2.2: 5 h / -78 °C / Inert atmosphere 3.1: 4-(N,N-dimethlyamino)pyridine; triethylamine; hydrogen / palladium 10 on activated carbon / tetrahydrofuran / 24 h / 20 °C View Scheme