5-N-叔丁氧羰基-5-N-甲基氨基-2-噻吩甲酸合成路线 （共 3 条）
反应条件
1: oxalyl chloride / dimethylformamide; CH2Cl2 / 0.5 h 2: Et3N / CH2Cl2 / 10 - 15 °C 3: 58 percent / CF3CO2HF / 16 h / 20 °C View Scheme
参考文献
Marsham, Peter R.; Hughes, Leslie R.; Jackman, Ann L.; Hayter, Anthony J.; Oldfield, John; et al.
Journal of Medicinal Chemistry, 1991 , vol. 34, # 5 p. 1594 - 1605
反应条件
1: oxalyl chloride / dimethylformamide; CH2Cl2 / 0.5 h 2: Et3N / CH2Cl2 / 10 - 15 °C 3: 58 percent / CF3CO2HF / 16 h / 20 °C 4: 22 percent / 2,6-lutidine / various solvent(s) / 18 h / 80 °C 5: 41 percent / 1 N aq. NaOH / 2 h View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 34, # 5 p. 1594 - 1605
反应条件
1: oxalyl chloride / dimethylformamide; CH2Cl2 / 0.5 h 2: Et3N / CH2Cl2 / 10 - 15 °C 3: 58 percent / CF3CO2HF / 16 h / 20 °C 4: 22 percent / 2,6-lutidine / various solvent(s) / 18 h / 80 °C View Scheme
参考文献
Marsham, Peter R.; Hughes, Leslie R.; Jackman, Ann L.; Hayter, Anthony J.; Oldfield, John; et al.
Journal of Medicinal Chemistry, 1991 , vol. 34, # 5 p. 1594 - 1605
