2,4,6-三甲氧基嘧啶合成路线 （共 12 条）
反应条件
sodium methylate; magnesium sulfate in methanol
反应条件
in toluene 12 h; Reflux;
参考文献
Arai, Satoshi; Okamura, Toshiya; Takeoka, Shinji
Tetrahedron Letters, 2010 , vol. 51, # 39 p. 5177 - 5180
反应条件
in methanol T=20°C; further solvent, various ratio of educts; Product distribution;
参考文献
Chemistry of Heterocyclic Compounds (New York, NY, United States), , vol. 23, # 11 p. 1218 - 1221
Khimiya Geterotsiklicheskikh Soedinenii, , # 11 p. 1523 - 1526
反应条件
in methanol T=20°C; further solvent, various ratio of educts; Product distribution;
参考文献
Chemistry of Heterocyclic Compounds (New York, NY, United States), , vol. 23, # 11 p. 1218 - 1221
Khimiya Geterotsiklicheskikh Soedinenii, , # 11 p. 1523 - 1526
反应条件
in methanol T=20°C; further solvent, various ratio of educts; Product distribution;
参考文献
Chemistry of Heterocyclic Compounds (New York, NY, United States), , vol. 23, # 11 p. 1218 - 1221
Khimiya Geterotsiklicheskikh Soedinenii, , # 11 p. 1523 - 1526
反应条件
in methanol T=20°C; further solvent, various ratio of educts; Product distribution;
参考文献
Chemistry of Heterocyclic Compounds (New York, NY, United States), , vol. 23, # 11 p. 1218 - 1221
Khimiya Geterotsiklicheskikh Soedinenii, , # 11 p. 1523 - 1526
反应条件
in diethyl ether T=20°C; 24 h; oth. solvents, oth. ratio of reagents; Product distribution;
参考文献
Journal of Organic Chemistry USSR (English Translation), , vol. 23, # 9 p. 1765 - 1769
Zhurnal Organicheskoi Khimii, , vol. 23, # 9 p. 1995 - 2000
反应条件
trifluoromethylsulfonic anhydride; NMe4NO3 in dichloromethane
20 h;
参考文献
Shackelford, Scott A.; Anderson, Mark B.; Christie, Lance C.; Goetzen, Thomas; Guzman, Mark C.; Hananel, Martha A.; Kornreich, Wayne D.; Li, Haitao; Pathak, Ved P.; Rabinovich, Alex K.; Rajapakse, Ranjan J.; Truesdale, Larry K.; Tsank, Stella M.; Vazir, Haresh N.
Journal of Organic Chemistry, 2003 , vol. 68, # 2 p. 267 - 275
反应条件
1: 2,4,6-trimethoxypyrimidine With n-butyllithium in tetrahydrofuran; diethyl ether; hexane
T=-30°C; 1.5 h; Inert atmosphere;
2: formic acid ethyl ester in tetrahydrofuran; diethyl ether; hexane
T=-70°C; 1 h; Inert atmosphere;
3: With hydrogenchloride in tetrahydrofuran; diethyl ether; ethanol; hexane; water
T=-70 - 0°C; Inert atmosphere;
参考文献
Arai, Satoshi; Okamura, Toshiya; Takeoka, Shinji
Tetrahedron Letters, 2010 , vol. 51, # 39 p. 5177 - 5180
参考文献
Fisher; Johnson
Journal of the American Chemical Society, 1932 , vol. 54, p. 727,731
