钆8,11-二(羧酸甲基)-14-{2-[(2-甲氧基乙基)氨基]-2-氧代乙基}-6-氧代-2-氧杂-5,8,11,14-四氮杂十六烷-16-酸酯合成路线 (共 3 条)
反应条件
1: N,N''-Bis[N-(2-methoxyethyl)-carbamoylmethyl]diethylenetriamine-N,N',N''-triacetic acid With hydrogenchloride in water pH=0.5 - 2.87; 2: gadolinium(III) oxide in water T=100°C; pH=0.5; 16.5 h; Heating / reflux; Product distribution / selectivity;
参考文献
MALLINCKRODT INC.
Patent: WO2007/142804 A2, 2007 ;
Location in patent: Page/Page column 25 ;
反应条件
1: 1,5-bis(2,6-dioxomorpholino)-3-azapentane-3-acetic acid; 2-(methoxy)ethylamine in water T=10°C; pH=3.2 - 13; 1.5 - 2 h; 2: gadolinium(III) nitrate in water pH=0.7; 0.833333 h; 3: With sodium hydroxide in water pH=7.7; Product distribution / selectivity;
参考文献
MALLINCKRODT INC.
Patent: WO2007/142804 A2, 2007 ;
Location in patent: Page/Page column 27-28 ;
反应条件
1: 2-(methoxy)ethylamine With hydrogenchloride in water T=18 - 52°C; pH=7.98 - 13.77; 2: 1,5-bis(2,6-dioxomorpholino)-3-azapentane-3-acetic acid With sodium hydroxide in water T=13 - 44.6°C; pH=2.19 - 8; 1.5 - 2.5 h; 3: gadolinium(III) oxide With hydrogenchloride Product distribution / selectivity; more than 3 stages;
参考文献
MALLINCKRODT INC.
Patent: WO2007/142804 A2, 2007 ;
Location in patent: Page/Page column 27-29 ;