1: With sodium methylate in methanol
T=20°C; 116 h;
2: With sulfuric acid in methanol
T=60°C; pH=1; 19 h;
3: With sodium carbonate in tert-butyl methyl ether; water
T=0°C; pH=9;
参考文献
F. HOFFMANN-LA ROCHE AG; KNUST, Henner; KOBLET, Andreas; NETTEKOVEN, Matthias; RATNI, Hasane; RIEMER, Claus; VIFIAN, Walter
Patent: WO2011/85886 A1, 2011 ;
Location in patent: Page/Page column 93 ;
WO 2011/085886 A1
