2-氨基-4,5-二氟苯硫醇合成路线 （共 4 条）
反应条件
sodium hydroxide in ethylene glycol T=125°C; 3 h;
参考文献
Van Zandt, Michael C.; Jones, Michael L.; Gunn, David E.; Geraci, Leo S.; Jones, J. Howard; Sawicki, Diane R.; Sredy, Janet; Jacot, Jorge L.; DiCioccio, A. Thomas; Petrova, Tatiana; Mitschler, Andre; Podjarny, Alberto D.
Journal of Medicinal Chemistry, 2005 , vol. 48, # 9 p. 3141 - 3152
反应条件
1: pyridine / 2 h / 120 °C 2: phosphorus pentasulfide / benzene / 3 h / Heating 3: NaH / toluene / 0.5 h / Heating 4: aq. NaOH / ethane-1,2-diol / 3 h / 125 °C View Scheme
参考文献
Van Zandt, Michael C.; Jones, Michael L.; Gunn, David E.; Geraci, Leo S.; Jones, J. Howard; Sawicki, Diane R.; Sredy, Janet; Jacot, Jorge L.; DiCioccio, A. Thomas; Petrova, Tatiana; Mitschler, Andre; Podjarny, Alberto D.
Journal of Medicinal Chemistry, 2005 , vol. 48, # 9 p. 3141 - 3152
反应条件
1: phosphorus pentasulfide / benzene / 3 h / Heating 2: NaH / toluene / 0.5 h / Heating 3: aq. NaOH / ethane-1,2-diol / 3 h / 125 °C View Scheme
参考文献
Van Zandt, Michael C.; Jones, Michael L.; Gunn, David E.; Geraci, Leo S.; Jones, J. Howard; Sawicki, Diane R.; Sredy, Janet; Jacot, Jorge L.; DiCioccio, A. Thomas; Petrova, Tatiana; Mitschler, Andre; Podjarny, Alberto D.
Journal of Medicinal Chemistry, 2005 , vol. 48, # 9 p. 3141 - 3152
参考文献
Mylari; Larson; Beyer; Zembrowski; Aldinger; Dee; Siegel; Singleton
Journal of Medicinal Chemistry, 1991 , vol. 34, # 1 p. 108 - 122
