N-Boc-2-哌啶乙酸甲酯合成路线 （共 24 条）
反应条件
1: 63 percent / NaBH(OAc)3 / acetic acid; acetonitrile / 52 h / 0 - 20 °C 2: H2 / Pd(OH)2/C / methanol / 4 h / 20 °C / 760 Torr 3: 0.19 g / NEt3 / CH2Cl2 / 15 h / 20 °C View Scheme
参考文献
Tetrahedron, , vol. 59, # 33 p. 6333 - 6339
反应条件
1: NaI; Na2CO3; tetrabutylammonium iodide / acetonitrile / Heating 2: 67 percent / BF3*Et2O / CH2Cl2 / 0 °C 3: 63 percent / NaBH(OAc)3 / acetic acid; acetonitrile / 52 h / 0 - 20 °C 4: H2 / Pd(OH)2/C / methanol / 4 h / 20 °C / 760 Torr 5: 0.19 g / NEt3 / CH2Cl2 / 15 h / 20 °C View Scheme
参考文献
Tetrahedron, , vol. 59, # 33 p. 6333 - 6339
反应条件
1: H2 / Pd(OH)2/C / methanol / 4 h / 20 °C / 760 Torr 2: 0.19 g / NEt3 / CH2Cl2 / 15 h / 20 °C View Scheme
参考文献
Tetrahedron, , vol. 59, # 33 p. 6333 - 6339
反应条件
1: 67 percent / BF3*Et2O / CH2Cl2 / 0 °C 2: 63 percent / NaBH(OAc)3 / acetic acid; acetonitrile / 52 h / 0 - 20 °C 3: H2 / Pd(OH)2/C / methanol / 4 h / 20 °C / 760 Torr 4: 0.19 g / NEt3 / CH2Cl2 / 15 h / 20 °C View Scheme
参考文献
Tetrahedron, , vol. 59, # 33 p. 6333 - 6339
反应条件
triethylamine in dichloromethane T=20°C; 15 h;
参考文献
Calvet, Sandrine; David, Olivier; Vanucci-Bacque, Corinne; Fargeau-Bellassoued, Marie-Claude; Lhommet, Gerard
Tetrahedron, 2003 , vol. 59, # 33 p. 6333 - 6339
反应条件
1: diazomethane; 2-isobutoxycarbonyloxycarbonyl-piperidine-1-carboxylic acid tert-butyl ester in diethyl ether T=0°C; Condensation; 3 h; 2: methanol With silver benzoate; triethylamine T=0 - 20°C; Arndt-Eistert's reaction; 3 h;
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 9, # 17 p. 2621 - 2624
反应条件
1: 9.32 g / hydrogen; aq. HCl / PtO2 / 50 h / 20 °C / 3750.3 Torr 2: 2.15 g / thionyl chloride / 3 h / Heating 3: 48 percent / triethylamine; 4-(dimethylamino)pyridine / CHCl3 / 24 h 4: Burkholderia cepacia PS-C II lipase / diisopropyl ether; butan-1-ol / 168 h / 47 °C View Scheme
参考文献
Tetrahedron Asymmetry, , vol. 18, # 2 p. 181 - 191
反应条件
Burkholderia cepacia PS-C II lipase in di-isopropyl ether; butan-1-ol T=47°C; 168 h;
参考文献
Liljeblad, Arto; Kavenius, Hanna-Maija; Taehtinen, Petri; Kanerva, Liisa T.
Tetrahedron Asymmetry, 2007 , vol. 18, # 2 p. 181 - 191
反应条件
Burkholderia cepacia PS-C II lipase in di-isopropyl ether T=20°C; 24 h;
参考文献
Tetrahedron Asymmetry, , vol. 18, # 2 p. 181 - 191
反应条件
Burkholderia cepacia PS-C II lipase in di-isopropyl ether T=20°C; 24 h;
参考文献
Tetrahedron Asymmetry, , vol. 18, # 2 p. 181 - 191
