5-(4-甲基苯基)-1H-吡咯-2-羧酸合成路线 （共 4 条）
反应条件
sodium hydroxide in ethanol Heating;
参考文献
Sobenina, L. N.; Sergeeva, M. P.; Mikhaleva, A. I.; Sigalov, M. V.; Korostova, S. E.; et al.
Chemistry of Heterocyclic Compounds (New York, NY, United States), 1990 , vol. 26, # 5 p. 516 - 520
Khimiya Geterotsiklicheskikh Soedinenii, 1990 , # 5 p. 612 - 616
反应条件
1: 78 percent / tetrahydrofuran / -40 °C 2: 87 percent / TFA / CH2Cl2 3: 1.) DDQ; 2.) 10percent NaOH / 1.) CH2Cl2, rt., 1 h; 2.) reflux, 12 h View Scheme
参考文献
Ezquerra, Jesus; Pedregal, Concepcion; Rubio, Almudena; Valenciano, Jesus; Garcia Navio, Jose Luis; Alvarez-Builla, Julio; Vaquero, Juan Jose
Tetrahedron Letters, 1993 , vol. 34, # 39 p. 6317 - 6320
反应条件
1: 78 percent / tetrahydrofuran / -40 °C 2: 87 percent / TFA / CH2Cl2 3: 1.) DDQ; 2.) 10percent NaOH / 1.) CH2Cl2, rt., 1 h; 2.) reflux, 12 h View Scheme
参考文献
Ezquerra, Jesus; Pedregal, Concepcion; Rubio, Almudena; Valenciano, Jesus; Garcia Navio, Jose Luis; Alvarez-Builla, Julio; Vaquero, Juan Jose
Tetrahedron Letters, 1993 , vol. 34, # 39 p. 6317 - 6320
反应条件
1: 87 percent / TFA / CH2Cl2 2: 1.) DDQ; 2.) 10percent NaOH / 1.) CH2Cl2, rt., 1 h; 2.) reflux, 12 h View Scheme
参考文献
Ezquerra, Jesus; Pedregal, Concepcion; Rubio, Almudena; Valenciano, Jesus; Garcia Navio, Jose Luis; Alvarez-Builla, Julio; Vaquero, Juan Jose
Tetrahedron Letters, 1993 , vol. 34, # 39 p. 6317 - 6320
