8-溴-5,6-二氟-2-甲基喹啉合成路线 （共 3 条）
反应条件
1: 2-Bromo-4,5-difluoroaniline With hydrogenchloride in water T=100°C; 2: (E)-crotonaldehyde in water; toluene 3 h; 3: With sodium hydroxide in water; toluene T=0°C;
参考文献
WO2006/98912 A1, ;
Page/Page column 55 ;
WO 2006/098912 A1
反应条件
hydrogenchloride; Fe2(S04)3; water; boric acid; m-nitrobenzene sulfonic acid sodium salt 1.) 0.5 h, reflux, 1.) 1 h, reflux; Yield given. Multistep reaction;
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 44, # 4 p. 642 - 645
反应条件
hydrogen; sodium acetate; palladium on activated charcoal in acetic acid
T=50°C; P=760 - 3800 Torr;
参考文献
Hashimoto, Koji; Okaichi, Yoshihiko; Nomi, Daisuke; Miyamoto, Hisashi; Bando, Masahiko; Kido, Masaru; Fujimura, Tsutomu; Furuta, Takuya; Minamikawa, Jun-Ichi
Chemical and Pharmaceutical Bulletin, 1996 , vol. 44, # 4 p. 642 - 645
