2-(吡啶-4-基)乙腈合成路线 （共 18 条）
反应条件
1: 47 percent / NaH / dimethylformamide / 24 h / Heating 2: H2O2 / acetic acid View Scheme
参考文献
Hung; Werbel
Journal of Heterocyclic Chemistry, 1984 , vol. 21, # 3 p. 741 - 744
反应条件
sodium tetrahydroborate; cobalt(II) chloride in methanol 3 h;
参考文献
Bell; Cantrell; Hogberg; Jaskunas; Johansson; Jordan; Kinnick; Lind; Morin Jr.; Noreen; Oberg; Palkowitz; Parrish; Pranc; Sahlberg; Ternansky; Vasileff; Vrang; West; et al.
Journal of Medicinal Chemistry, 1995 , vol. 38, # 25 p. 4929 - 4936
反应条件
1: DMA / toluene / Heating 2: N2H2*HCl / ethanol / Heating View Scheme
参考文献
Fraley, Mark E.; Hoffman, William F.; Rubino, Robert S.; Hungate, Randall W.; Tebben, Andrew J.; Rutledge, Ruth Z.; McFall, Rosemary C.; Huckle, William R.; Kendall, Richard L.; Coll, Kathleen E.; Thomas, Kenneth A.
Bioorganic and Medicinal Chemistry Letters, 2002 , vol. 12, # 19 p. 2767 - 2770
反应条件
1: With sodium hydroxide; phenylmethyltriethylammonium bromide in water
T=20 - 50°C; 4.25 h;
2: With ammonia; hydrogen; nickel in methanol; water
P=2585.81 Torr;
参考文献
ELIAN PHARMACEUTICALS INC
Patent: WO2004/33436 A1, 2004 ;
Location in patent: Page 69 ;
WO 2004/033436 A1
反应条件
Rhodium trichloride; sodium carbonate; triphenylphosphine
20 h; Heating;
参考文献
Leung; Rowlands; Jarman; Foster; Griggs; Wilman
Journal of Medicinal Chemistry, 1987 , vol. 30, # 9 p. 1550 - 1554
反应条件
2: acetic acid, H2SO4, HCl / 3.5 h / Heating
View Scheme
参考文献
Leung; Rowlands; Jarman; Foster; Griggs; Wilman
Journal of Medicinal Chemistry, 1987 , vol. 30, # 9 p. 1550 - 1554
参考文献
Foster, Allan B.; Jarman, Michael; Leung, Chui-Sheung; Rowlands, Martin G.; Taylor, Grahame N.; et al.
Journal of Medicinal Chemistry, 1985 , vol. 28, # 2 p. 200 - 204
反应条件
hydrogen sulfide; ammonia in methanol
T=0 - 25°C; 16.5 h;
参考文献
GRUeNENTHAL GMBH
Patent: WO2009/124746 A1, 2009 ;
Location in patent: Page/Page column 196 ;
