N-苄氧羰基-L-苯丙氨酰基-L-苯丙氨酸合成路线 （共 27 条）
反应条件
tetra(n-butyl)ammonium hydroxide in water; dimethyl sulfoxide T=0°C; 0.5 h; Reagent/catalystSolvent;
参考文献
Verardo; Gorassini
Journal of Peptide Science, 2013 , vol. 19, # 5 p. 315 - 324
反应条件
Tris buffer; triethylamine; α-chymotrypsin in acetonitrile T=30°C; Acylation; pH=7.8; 1 h;
参考文献
Miyazawa, Toshifumi; Ensatsu, Eiichi; Tanaka, Kayoko; Yanagihara, Ryoji; Yamada, Takashi
Chemistry Letters, 1999 , # 10 p. 1013 - 1014
反应条件
(i) NaI, DMF, (ii) Zn, MeCN; Multistep reaction;
参考文献
Buchholz, Michael; Kunz, Horst
Liebigs Annalen der Chemie, 1983 , # 11 p. 1859 - 1885
反应条件
1: SOCl2 2: dicyclohexylcarbodiimide 3: NaOH / H2O / 3 h / 20 °C View Scheme
参考文献
Kanosue, Yoshifumi; Kojima, Satoshi; Hiraga, Yoshikazu; Ohkata, Katsuo
Bulletin of the Chemical Society of Japan, 2004 , vol. 77, # 6 p. 1187 - 1193
反应条件
1: dicyclohexylcarbodiimide 2: NaOH / H2O / 3 h / 20 °C View Scheme
参考文献
Kanosue, Yoshifumi; Kojima, Satoshi; Hiraga, Yoshikazu; Ohkata, Katsuo
Bulletin of the Chemical Society of Japan, 2004 , vol. 77, # 6 p. 1187 - 1193
反应条件
1: dicyclohexylcarbodiimide 2: NaOH / H2O / 3 h / 20 °C View Scheme
参考文献
Kanosue, Yoshifumi; Kojima, Satoshi; Hiraga, Yoshikazu; Ohkata, Katsuo
Bulletin of the Chemical Society of Japan, 2004 , vol. 77, # 6 p. 1187 - 1193
反应条件
1: SOCl2 / 3 h / 90 °C 2: 2N NaOH / acetone; H2O / 0 deg C, 20 min, pH: 9-11, then rt., 30 min View Scheme
参考文献
Amino; Kawada; Toi; Kumashiro; Fukushima
Chemical and Pharmaceutical Bulletin, 1988 , vol. 36, # 11 p. 4426 - 4434
反应条件
sodium hydroxide in water; acetone 0 deg C, 20 min, pH: 9-11, then rt., 30 min;
参考文献
Amino; Kawada; Toi; Kumashiro; Fukushima
Chemical and Pharmaceutical Bulletin, 1988 , vol. 36, # 11 p. 4426 - 4434
反应条件
1: HBr / acetic acid 2: 87 percent / EDC*HCl; HOBT; Et3N / dimethylformamide / 20 °C 3: 4.2 percent Chromat. / Et3N; α-chymotrypsin immobilised on Celite / acetonitrile; various solvent(s) / 1 h / 30 °C / pH 7.8 View Scheme
参考文献
Miyazawa, Toshifumi; Ensatsu, Eiichi; Hiramatsu, Makoto; Yanagihara, Ryoji; Yamada, Takashi
Journal of the Chemical Society. Perkin Transactions 1, 2002 , # 3 p. 396 - 401
反应条件
in water T=0°C; 0.5 h;
参考文献
Noguchi, Takuya; Tehara, Naoka; Uesugi, Yuki; Jung, Seunghee; Imai, Nobuyuki
Chemistry Letters, 2012 , vol. 41, # 1 p. 42 - 43
