in acetonitrile 72 h; Reflux;

1.1: methanol-d4; sodium formate; water-d2 / palladium on carbon / 160 °C 2.1: sodium hydrogencarbonate; iodine cloride / dichloromethane; methanol / 0.67 h 3.1: sodium acetate / palladium on carbon / N,N-dimethyl acetamide / 130 °C 3.2: 0.5 h / 60 °C 4.1: acetonitrile / 72 h / Reflux View Scheme

1.1: sodium hydrogencarbonate; iodine cloride / dichloromethane; methanol / 0.67 h 2.1: sodium acetate / palladium on carbon / N,N-dimethyl acetamide / 130 °C 2.2: 0.5 h / 60 °C 3.1: acetonitrile / 72 h / Reflux View Scheme