N-乙基-3-苯基-1-丙胺合成路线 （共 19 条）
反应条件
lithium aluminium tetrahydride in tetrahydrofuran
0.5 h; Ambient temperature;
参考文献
Ishihara; Kato; Goto
Chemical and Pharmaceutical Bulletin, 1991 , vol. 39, # 12 p. 3225 - 3235
反应条件
sodium borohydride in ethanol; dichloromethane; water
参考文献
L'OREAL
Patent: US2004/143009 A1, 2004 ;
反应条件
1: in methanol; ethanol
T=20°C; 20 h;
2: With sodium tetrahydroborate in methanol; ethanol
T=20°C; 20 h;
参考文献
L'OREAL
Patent: US2005/8607 A1, 2005 ;
Location in patent: Page/Page column 5 ;
反应条件
1: 85 percent / triethylamine / tetrahydrofuran
2: 82 percent / 1,1,3,3-tetramethyldisiloxane / (μ3,η2,η3,η5-acenaphthylene)Ru(CO)7 / 1,2-dimethoxy-ethane / 8 h / 40 °C
View Scheme
参考文献
Hanada, Shiori; Ishida, Toshiki; Motoyama, Yukihiro; Nagashima, Hideo
Journal of Organic Chemistry, 2007 , vol. 72, # 20 p. 7551 - 7559
反应条件
phosphoric acid in acetic acid
T=115°C; 5 h; Yield given. Yields of byproduct given;
参考文献
Cohen, Theodore; Onopchenko, Anatoli
Journal of Organic Chemistry, 1983 , vol. 48, # 24 p. 4531 - 4537
反应条件
lithium aluminium tetrahydride; aluminium trichloride in tetrahydrofuran; diethyl ether
1 h; Heating; Yield given;
参考文献
Jaen; Wise; Heffner; Pugsley; Meltzer
Journal of Medicinal Chemistry, 1991 , vol. 34, # 1 p. 248 - 256
反应条件
1: triethylamine / CHCl3 / Ambient temperature; overnight
2: aluminum chloride, lithium aluminum hydride / tetrahydrofuran; diethyl ether / 1 h / Heating
View Scheme
参考文献
Jaen; Wise; Heffner; Pugsley; Meltzer
Journal of Medicinal Chemistry, 1991 , vol. 34, # 1 p. 248 - 256
反应条件
hydrogenchloride
T=160 - 170°C; im Einschlussrohr;
参考文献
v. Braun
Chemische Berichte, 1910 , vol. 43, p. 3216
反应条件
potassium hydroxide
T=120°C;
参考文献
Kuelz et al.
Chemische Berichte, 1939 , vol. 72, p. 2161,2166
反应条件
acetic acid; platinum
Hydrogenation;
参考文献
Skita; Wulff
Justus Liebigs Annalen der Chemie, 1927 , vol. 455, p. 35
