1: diethyl ether / und beim Behandeln der Reaktionsloesung mit wss.Salzsaeure
2: lithium alanate; diethyl ether
3: potassium hydrogen sulfate / 160 °C / unter vermindertem Druck und Hydrieren des erhaltenen Olefin-Gemisches an Raney-Nickel in Methylcyclohexan bei 180grad/220 at
View Scheme
参考文献
Rabjohn et al.
Journal of Organic Chemistry, 1959 , vol. 24, p. 1964,1966,1968
in tetrahydrofuran
T=0 - 20°C; 2.08333 h; Inert atmosphere;
参考文献
Hodgkinson, James T.; Galloway, Warren R. J. D.; Saraf, Shreya; Baxendale, Ian R.; Ley, Steven V.; Ladlow, Mark; Welch, Martin; Spring, David R.
Organic and Biomolecular Chemistry, 2011 , vol. 9, # 1 p. 57 - 61
Hager; Marvel
Journal of the American Chemical Society, 1926 , vol. 48, p. 2695
Full Text Show Details
Gilman; Brown
Journal of the American Chemical Society, 1929 , vol. 51, p. 928
Journal of the American Chemical Society, 1930 , vol. 52, p. 3315
1: With copper(I) bromide in diethyl ether
0.5 h; Heating;
2: With sulfuric acid in diethyl ether; water
T=20°C; 24 h;
参考文献
Lenkowski, Paul W.; Ko, Seong-Hoon; Anderson, James D.; Brown, Milton L.; Patel, Manoj K.
European Journal of Pharmaceutical Sciences, 2004 , vol. 21, # 5 p. 635 - 644