N-皮丁基-4-雄烯-3-酮-17beta-羧酰胺合成路线 （共 15 条）
反应条件
T=5°C; 0.5 h; Yield given;
参考文献
RANBAXY LABORATORIES LIMITED
Patent: WO2005/75497 A1, 2005 ;
Location in patent: Page/Page column 7 ;
反应条件
1: SOCl2; pyridine / toluene / 3 h / 5 °C 2: 1.50 g / toluene / 0.5 h / 5 °C View Scheme
参考文献
Bhattacharya, A.; Williams, J.M.; Amato, J.S.; Dolling, U.-H.; Grabowski, E.J.J.
Synthetic Communications, 1990 , vol. 20, # 17 p. 2683 - 2690
反应条件
1: 70.62 percent / Al(i-PrO)3 / cyclohexanone; toluene / 4 h / Heating 2: 100 percent / aq. KOH / methanol / 5 h / Heating 3: SOCl2; pyridine / toluene / 3 h / 5 °C 4: 1.50 g / toluene / 0.5 h / 5 °C View Scheme
参考文献
Fei, Xiang-Shu; Tian, Wei-Sheng; Chen, Qing-Yun
Bioorganic and Medicinal Chemistry Letters, 1997 , vol. 7, # 24 p. 3113 - 3118
反应条件
1: 100 percent / aq. KOH / methanol / 5 h / Heating 2: SOCl2; pyridine / toluene / 3 h / 5 °C 3: 1.50 g / toluene / 0.5 h / 5 °C View Scheme
参考文献
Fei, Xiang-Shu; Tian, Wei-Sheng; Chen, Qing-Yun
Bioorganic and Medicinal Chemistry Letters, 1997 , vol. 7, # 24 p. 3113 - 3118
参考文献
Sankyo Company, Limited
Patent: US5536714 A1, 1996 ;
反应条件
1: I2 / 1.5 h / Heating 2: methanol / 1 h / Heating 3: 70.62 percent / Al(i-PrO)3 / cyclohexanone; toluene / 4 h / Heating 4: 100 percent / aq. KOH / methanol / 5 h / Heating 5: SOCl2; pyridine / toluene / 3 h / 5 °C 6: 1.50 g / toluene / 0.5 h / 5 °C View Scheme
参考文献
Xia, Peng; Yang, Zheng-Yu; Xia, Yi; Zheng, Yun-Qing; Cosentino, L.Mark; Lee, Kuo-Hsiung
Bioorganic and Medicinal Chemistry, 1999 , vol. 7, # 9 p. 1907 - 1911
反应条件
1: methanol / 1 h / Heating 2: 70.62 percent / Al(i-PrO)3 / cyclohexanone; toluene / 4 h / Heating 3: 100 percent / aq. KOH / methanol / 5 h / Heating 4: SOCl2; pyridine / toluene / 3 h / 5 °C 5: 1.50 g / toluene / 0.5 h / 5 °C View Scheme
参考文献
Xia, Peng; Yang, Zheng-Yu; Xia, Yi; Zheng, Yun-Qing; Cosentino, L.Mark; Lee, Kuo-Hsiung
Bioorganic and Medicinal Chemistry, 1999 , vol. 7, # 9 p. 1907 - 1911
反应条件
1: 82 percent / p-toluenesulfonic acid / 5 h / Heating 2: 87 percent / Al(i-PrO)3, cyclohexanone / toluene 3: 95 percent / KOH / ethanol; H2O 4: 1.) oxalyl chloride, pyridine / 1.) toluene, 1 h, 2.) toluene, 1 h View Scheme
参考文献
Fei, Xiang-Shu; Tian, Wei-Sheng; Chen, Qing-Yun
Bioorganic and Medicinal Chemistry Letters, 1997 , vol. 7, # 24 p. 3113 - 3118
反应条件
1: 1.) NaOBr, 2.) HCl / 1.) dioxane, water 2: 82 percent / p-toluenesulfonic acid / 5 h / Heating 3: 87 percent / Al(i-PrO)3, cyclohexanone / toluene 4: 95 percent / KOH / ethanol; H2O 5: 1.) oxalyl chloride, pyridine / 1.) toluene, 1 h, 2.) toluene, 1 h View Scheme
参考文献
Fei, Xiang-Shu; Tian, Wei-Sheng; Chen, Qing-Yun
Bioorganic and Medicinal Chemistry Letters, 1997 , vol. 7, # 24 p. 3113 - 3118
反应条件
pyridine; oxalyl dichloride 1.) toluene, 1 h, 2.) toluene, 1 h; Yield given. Multistep reaction;
参考文献
Fei, Xiang-Shu; Tian, Wei-Sheng; Chen, Qing-Yun
Bioorganic and Medicinal Chemistry Letters, 1997 , vol. 7, # 24 p. 3113 - 3118
