3-羟基-5-苯基-1,3-二氢-苯并[e][1,4]二氮杂革-2-酮合成路线 （共 7 条）
反应条件
1: 3 h / 70 °C 2: 900 mg / aq. NaOH / methanol / 2 h View Scheme
参考文献
Middleton, W. J.; Bingham, E. M.; Smith, D. H.
Journal of Fluorine Chemistry, 1983 , vol. 23, p. 557 - 572
反应条件
sodium hydrogencarbonate in ethanol T=25°C; 18 h; Yield given;
参考文献
Middleton, W. J.; Bingham, E. M.; Smith, D. H.
Journal of Fluorine Chemistry, 1983 , vol. 23, p. 557 - 572
反应条件
sodium hydroxide in methanol 2 h;
参考文献
Carter, Malcolm C.; Alber, Dagmar G.; Baxter, Robert C.; Bithell, Sian K.; Budworth, Jo; Chubb, Ann; Cockerill, G. Stuart; Dowdell, Verity C. L.; Henderson, Elisa A.; Keegan, Sally J.; Kelsey, Richard D.; Lockyer, Michael J.; Stables, Jeremy N.; Wilson, Lara J.; Powell, Kenneth L.
Journal of Medicinal Chemistry, 2006 , vol. 49, # 7 p. 2311 - 2319
反应条件
1.1: CH2Cl2; H2O 1.2: NH3 2.1: m-chloroperbenzoic acid / CH2Cl2 / 18 h 3.1: 3 h / 70 °C 4.1: 900 mg / aq. NaOH / methanol / 2 h View Scheme
参考文献
Carter, Malcolm C.; Alber, Dagmar G.; Baxter, Robert C.; Bithell, Sian K.; Budworth, Jo; Chubb, Ann; Cockerill, G. Stuart; Dowdell, Verity C. L.; Henderson, Elisa A.; Keegan, Sally J.; Kelsey, Richard D.; Lockyer, Michael J.; Stables, Jeremy N.; Wilson, Lara J.; Powell, Kenneth L.
Journal of Medicinal Chemistry, 2006 , vol. 49, # 7 p. 2311 - 2319
反应条件
1: m-chloroperbenzoic acid / CH2Cl2 / 18 h 2: 3 h / 70 °C 3: 900 mg / aq. NaOH / methanol / 2 h View Scheme
参考文献
Carter, Malcolm C.; Alber, Dagmar G.; Baxter, Robert C.; Bithell, Sian K.; Budworth, Jo; Chubb, Ann; Cockerill, G. Stuart; Dowdell, Verity C. L.; Henderson, Elisa A.; Keegan, Sally J.; Kelsey, Richard D.; Lockyer, Michael J.; Stables, Jeremy N.; Wilson, Lara J.; Powell, Kenneth L.
Journal of Medicinal Chemistry, 2006 , vol. 49, # 7 p. 2311 - 2319
反应条件
diethylamino-sulfur trifluoride in dichloromethane
1.) -70 deg C, 2.) to -10 deg C, 25 min;
参考文献
Middleton, W. J.; Bingham, E. M.; Smith, D. H.
Journal of Fluorine Chemistry, 1983 , vol. 23, p. 557 - 572
反应条件
1: 88 percent / diethylaminosulfur trifluoride / CH2Cl2 / 1.) -70 deg C, 2.) to -10 deg C, 25 min
2: 53 percent / sodium hydride / tetrahydrofuran / 3 h / 25 °C
View Scheme
参考文献
Middleton, W. J.; Bingham, E. M.; Smith, D. H.
Journal of Fluorine Chemistry, 1983 , vol. 23, p. 557 - 572
