11-甲基-11H-苯并[a]咔唑合成路线 （共 12 条）
反应条件
caesium carbonate in N,N-dimethyl-formamide T=200°C; 1.5 h; microwave irradiation;
参考文献
Monsieurs, Katrien; Rombouts, Geert; Tapolcsanyi, Pal; Matyus, Peter; Maes, Bert U. W.
Synlett, 2006 , # 19 p. 3225 - 3230
反应条件
sodium hydride in N,N-dimethyl-formamide
参考文献
Kulagowski, Janusz J.; Moody, Christopher J.; Rees, Charles W.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1985 , p. 2733 - 2740
反应条件
1.1: KHMDS / toluene; tetrahydrofuran / 0.75 h / -78 °C 1.2: 791 mg / tetrahydrofuran; toluene / 1.25 h / -78 - 20 °C 2.1: 85 percent / aq. Na2CO3 / Pd(PPh3)4 / 1,2-dimethoxy-ethane; ethanol / 18 h / Heating 3.1: 77 percent / tert-BuOK / dimethylformamide / 0.17 h / 80 °C / UV-irradiation View Scheme
参考文献
De Koning, Charles B.; Michael, Joseph P.; Rousseau, Amanda L.
Tetrahedron Letters, 1998 , vol. 39, # 47 p. 8725 - 8728
反应条件
1: 85 percent / aq. Na2CO3 / Pd(PPh3)4 / 1,2-dimethoxy-ethane; ethanol / 18 h / Heating 2: 77 percent / tert-BuOK / dimethylformamide / 0.17 h / 80 °C / UV-irradiation View Scheme
参考文献
De Koning, Charles B.; Michael, Joseph P.; Rousseau, Amanda L.
Journal of the Chemical Society, Perkin Transactions 1, 2000 , # 11 p. 1705 - 1713
反应条件
1: 76 percent / potassium (bistrimethylsilyl)amide 2: 77 percent / potassium t-butoxide / dimethylformamide / 0.33 h / 80 °C / Irradiation View Scheme
参考文献
De Koning, Charles B.; Michael, Joseph P.; Rousseau, Amanda L.
Tetrahedron Letters, 1998 , vol. 39, # 47 p. 8725 - 8728
反应条件
1: 1.) LDA; 3.) AcOH, BF3*Et2O / 1.) THF/hexane/HMPA, -78 deg C, 3 h; 2.) 105 deg C, 1.25 h; 3.) reflux, 3 h 2: 64 percent / palladium on charcoal / 0.5 h / 215 °C 3: 59 percent / sodium hydride / dimethylformamide View Scheme
参考文献
Buu-Hoi; Jacquignon
Journal of the Chemical Society, 1956 , p. 1518
Bulletin de la Societe Chimique de France, 1957 , p. 488,498
反应条件
T=640°C; P=0.03 Torr;
参考文献
Kulagowski, Janusz J.; Moody, Christopher J.; Rees, Charles W.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1985 , p. 2733 - 2740
反应条件
1: 64 percent / palladium on charcoal / 0.5 h / 215 °C 2: 59 percent / sodium hydride / dimethylformamide View Scheme
参考文献
Kulagowski, Janusz J.; Moody, Christopher J.; Rees, Charles W.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1985 , p. 2733 - 2740
反应条件
1: 29 mg / 640 °C / 0.03 Torr 2: 59 percent / sodium hydride / dimethylformamide View Scheme
参考文献
Kulagowski, Janusz J.; Moody, Christopher J.; Rees, Charles W.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1985 , p. 2733 - 2740
反应条件
sodium amide; toluene anschliessend mit Methylhalogenid;
参考文献
Buu-Hoi
Journal of the Chemical Society, 1946 , p. 795
