5-溴-3-(1-丙炔-1-基)-2-吡啶胺合成路线 （共 3 条）
反应条件
potassium tert-butylate in tert-butyl alcohol T=85°C; 1 h;
参考文献
F. HOFFMANN-LA ROCHE AG; DYKE, Hazel Joan; GAZZARD, Lewis J.; WILLIAMS, Karen
Patent: WO2011/73263 A1, 2011 ;
Location in patent: Page/Page column 79 ;
WO 2011/073263 A1
反应条件
1.1: potassium tert-butylate / tert-butyl alcohol / 1 h / 85 °C 2.1: AlCl3, aluminium chloride / dichloromethane / 0.83 h 2.2: 18 h View Scheme
参考文献
F. HOFFMANN-LA ROCHE AG; DYKE, Hazel Joan; GAZZARD, Lewis J.; WILLIAMS, Karen
Patent: WO2011/73263 A1, 2011 ;
WO 2011/073263 A1
反应条件
1.1: potassium tert-butylate / tert-butyl alcohol / 1 h / 85 °C 2.1: AlCl3, aluminium chloride / dichloromethane / 0.83 h 2.2: 18 h 3.1: sodium hydroxide; N-benzyl-N,N,N-triethylammonium chloride / dichloromethane / 1.33 h / 0 - 20 °C View Scheme
参考文献
F. HOFFMANN-LA ROCHE AG; DYKE, Hazel Joan; GAZZARD, Lewis J.; WILLIAMS, Karen
Patent: WO2011/73263 A1, 2011 ;
WO 2011/073263 A1
