N-(9-芴甲氧羰基)-N’-(2-乙酰氨基-2-脱氧-3,4,6-三-O-乙酰基-beta-D-吡喃葡萄糖基)-L-天冬酰胺合成路线 （共 13 条）
反应条件
trifluoroacetic acid in water T=20°C; 3 h;
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 21, # 17 p. 4973 - 4975
反应条件
in dimethyl sulfoxide T=20°C; 1 h;
参考文献
Tetrahedron Letters, , vol. 50, # 46 p. 6351 - 6354
反应条件
1: 87 percent / H2 / Lindlar catalyst / ethanol / 20 h / 20 °C 2: 100 percent / 2,6-di-t-butyl-4-methylpyridine / CH2Cl2 / 0.67 h / 20 °C 3: 82 percent / Bu4NF / CH2Cl2 / 20 °C 4: TFA / CH2Cl2 / 1.5 h / 20 °C View Scheme
参考文献
Tetrahedron Letters, , vol. 41, # 7 p. 1039 - 1042
反应条件
1: 90 percent / Me3SiOMe; H2 / Lindlar catalyst / tetrahydrofuran / 18 h / 20 °C 2: TFA / CH2Cl2 / 1.5 h / 20 °C View Scheme
参考文献
Tetrahedron Letters, , vol. 41, # 7 p. 1039 - 1042
反应条件
1: 100 percent / 2,6-di-t-butyl-4-methylpyridine / CH2Cl2 / 0.67 h / 20 °C 2: 82 percent / Bu4NF / CH2Cl2 / 20 °C 3: TFA / CH2Cl2 / 1.5 h / 20 °C View Scheme
参考文献
Tetrahedron Letters, , vol. 41, # 7 p. 1039 - 1042
反应条件
1: 82 percent / Bu4NF / CH2Cl2 / 20 °C 2: TFA / CH2Cl2 / 1.5 h / 20 °C View Scheme
参考文献
Tetrahedron Letters, , vol. 41, # 7 p. 1039 - 1042
反应条件
1: DIPEA / dimethylsulfoxide / 1.) r.t., 10 min, 2.) r.t. 2: pyridine / 12 h / 22 °C 3: TFA / 1 h / Ambient temperature View Scheme
参考文献
Journal of the Chemical Society - Perkin Transactions 1, , # 3 p. 549 - 560
反应条件
1: aq. NH4HCO3 / 45 °C 2: DIPEA / dimethylsulfoxide / 1.) r.t., 10 min, 2.) r.t. 3: pyridine / 12 h / 22 °C 4: TFA / 1 h / Ambient temperature View Scheme
参考文献
Journal of the Chemical Society - Perkin Transactions 1, , # 3 p. 549 - 560
反应条件
1: 1.) DCCI / 1.) THF, -35 deg C, 10 min, 2.) -35 deg C, 2 h; -35 deg C to r.t. 2: DIPEA / dimethylsulfoxide / 1.) r.t., 10 min, 2.) r.t. 3: pyridine / 12 h / 22 °C 4: TFA / 1 h / Ambient temperature View Scheme
参考文献
Journal of the Chemical Society - Perkin Transactions 1, , # 3 p. 549 - 560
反应条件
1: DIPEA / dimethylsulfoxide / 1.) r.t., 10 min, 2.) r.t. 2: pyridine / 12 h / 22 °C 3: TFA / 1 h / Ambient temperature View Scheme
参考文献
Journal of the Chemical Society - Perkin Transactions 1, , # 3 p. 549 - 560
