(S)-2-氨基-3-环己基-1-丙醇合成路线 （共 6 条）
反应条件
hydrogenchloride in 1,4-dioxane; dichloromethane T=20°C; 16 h;
参考文献
SCHERING CORPORATION; PHARMACOPEIA DRUG DISCOVERY, INC
Patent: WO2005/16876 A2, 2005 ;
Location in patent: Page/Page column 35 ;
WO 2005/016876 A2
反应条件
hydrogenchloride; hydrogen; Rh/Al2O3 in water T=20°C; Hydrogenation; P=750.06 Torr;
参考文献
Strotmann; Butenschon
Synthetic Communications, 2000 , vol. 30, # 22 p. 4173 - 4176
反应条件
hydrogen; Nishimura catalyst <(45.9percent Rh/19.9percent Pt) oxide> in methanol T=25°C; P=75007.5 Torr;
参考文献
Studer, Martin; Burkhardt, Stefan; Blaser, Hans-Ulrich
Advanced Synthesis and Catalysis, 2001 , vol. 343, # 8 p. 802 - 808
参考文献
Brunner, Henri; Ittner, Karl-Peter; Lunz, Dirk; Schmatloch, Stefan; Schmidt, Thomas; Zabel, Manfred
European Journal of Organic Chemistry, 2003 , # 5 p. 855 - 862
反应条件
1: H2 / Rh-Al2O3 / 3040 Torr 2: 98.5 percent / HCl View Scheme
参考文献
Harada; Tsubaki; Kamijo; Iizuka; Kiso
Chemical and Pharmaceutical Bulletin, 1989 , vol. 37, # 9 p. 2570 - 2572
反应条件
triethylamine in N,N-dimethyl-formamide a) 0 deg C, 30 min, b) RT, 2 h; Yield given;
参考文献
Fournie-Zaluski; Coric; Turcaud; Bruetschy; Lucas; Noble; Roques
Journal of Medicinal Chemistry, 1992 , vol. 35, # 7 p. 1259 - 1266
