4,5,6,7-四氢-1-苯并噻吩合成路线 （共 18 条）
反应条件
potassium hydroxide; hydrazine hydrate in diethylene glycol T=180°C; 8 h;
参考文献
European Journal of Medicinal Chemistry, , vol. 33, # 11 p. 867 - 877
反应条件
1: diethyl (mercaptomethyl)phosphonate With sodium hydride in tetrahydrofuran T=0°C; 0.25 h; 2: (2-chlorocyclohex-1-enyl)carboxaldehyde in tetrahydrofuran T=20°C; 19 h; Inert atmosphere;
参考文献
Tetrahedron Letters, , vol. 55, # 7 p. 1332 - 1335
反应条件
1: polyphosphoric acid; acetic anhydride View Scheme
参考文献
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, , vol. 39, # 5 p. 334 - 338
反应条件
2: polyphosphoric acid; acetic anhydride View Scheme
参考文献
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, , vol. 39, # 5 p. 334 - 338
反应条件
hydrogen bromide; acetic anhydride T=100°C;
参考文献
Angewandte Chemie, , vol. 102, # 4 p. 414 - 415
反应条件
Lawesson's reagent in toluene 4 h; Heating;
参考文献
Monatshefte fuer Chemie, , vol. 117, p. 621 - 630
反应条件
1: 1-methylpiperazine / CH2Cl2 / 3 h / 0 °C 2: 36percent aq. HCl (pH 1-2) / 1 h / 20 °C View Scheme
参考文献
Helvetica Chimica Acta, , vol. 75, # 3 p. 907 - 912
反应条件
1: aluminium chloride 2: hydrazine hydrate; potassium hydroxide; diethylene glycol / 215 °C View Scheme
参考文献
Bulletin de la Societe Chimique de France, , p. 62,68, 713, 717
反应条件
N-bromosuccinmide in chloroform T=0 - 40°C;
参考文献
GENENTECH, INC.
Patent: WO2009/151598 A1, 2009 ;
Location in patent: Page/Page column 146-147 ;
WO 2009/151598 A1
