4,5,6,7-四氢-1-苯并噻吩合成路线 （共 18 条）
反应条件
n-butyllithium in diethyl ether; hexane T=-50°C; Carboxylation; 4 h;
参考文献
Mitschke, Ullrich; Debaerdemaeker, Tony; Baeuerle, Peter
European Journal of Organic Chemistry, 2000 , # 3 p. 425 - 437
反应条件
1: aluminium chloride 2: alkaline aqueous potassium hypobromite solution; dioxane View Scheme
参考文献
Cagniant; Cagniant
Bulletin de la Societe Chimique de France, 1955 , p. 1252,1255
反应条件
aluminium trichloride in carbon disulfide Acylation; 20 h; Heating;
参考文献
Mitschke, Ullrich; Debaerdemaeker, Tony; Baeuerle, Peter
European Journal of Organic Chemistry, 2000 , # 3 p. 425 - 437
反应条件
1: 89 percent / nBuLi / hexane; diethyl ether / 4 h / -50 °C 2: oxalyl chloride / toluene / 3 h / 55 °C View Scheme
参考文献
Mitschke, Ullrich; Debaerdemaeker, Tony; Baeuerle, Peter
European Journal of Organic Chemistry, 2000 , # 3 p. 425 - 437
反应条件
1: aluminium chloride; nitrobenzene 2: hydrazine; potassium hydroxide; diethylene glycol / 210 °C 3: thionyl chloride / Behandeln mit Zinn(IV)-chlorid in Schwefelkohlenstoff 4: hydrazine hydrate; potassium hydroxide; diethylene glycol View Scheme
参考文献
Cagniant; Cagniant
Bulletin de la Societe Chimique de France, 1952 , p. 336,340
反应条件
ammonium cerium(IV) nitrate; acetic acid 0.5 h; Ambient temperature;
参考文献
Pinna, Gerard Aime; Pirisi, Maria Antonietta; Paglietti, Giuseppe
Journal of Chemical Research, Miniprint, 1993 , # 6 p. 1279 - 1296
反应条件
chlorosulfonic acid in chloroform T=0°C; 0.5 h;
参考文献
Mohamadi; Spees; Grindey
Journal of Medicinal Chemistry, 1992 , vol. 35, # 16 p. 3012 - 3016
反应条件
1: aluminium chloride
2: alkaline aqueous potassium hypobromite solution; dioxane
3: thionyl chloride / Behandeln des Reaktionsprodukts mit wss. Ammoniak
View Scheme
参考文献
Cagniant; Cagniant
Bulletin de la Societe Chimique de France, 1953 , p. 62,68, 713, 717
