sodium methylate in methanol; dichloromethane 1 h; Ambient temperature;

sodium methylate in 1,4-dioxane 20 h; Ambient temperature;

1: 84.6 percent / ethanol; H2O / 24 h / Heating 2: 1.) potassium iodide; 2.) lead tetraacetate / 1.) glacial CH3COOH, 60 dec C, 15-20 min; 2.) 1 h. 3: 87 percent / sodium methoxide / CH2Cl2; methanol / 1 h / Ambient temperature View Scheme

1: 30percent HCl / methanol 2: 79 percent / 15percent ethanolic amonia / ethanol / 24 h / Heating 3: 1.) potassium iodide; 2.) lead tetraacetate / 1.) glacial CH3COOH, 60 dec C, 15-20 min; 2.) 1 h. 4: 87 percent / sodium methoxide / CH2Cl2; methanol / 1 h / Ambient temperature View Scheme

1: 79 percent / 15percent ethanolic amonia / ethanol / 24 h / Heating 2: 1.) potassium iodide; 2.) lead tetraacetate / 1.) glacial CH3COOH, 60 dec C, 15-20 min; 2.) 1 h. 3: 87 percent / sodium methoxide / CH2Cl2; methanol / 1 h / Ambient temperature View Scheme

1: 95 percent / acetonitrile / 4 h / Ambient temperature 2: 84.6 percent / ethanol; H2O / 24 h / Heating 3: 1.) potassium iodide; 2.) lead tetraacetate / 1.) glacial CH3COOH, 60 dec C, 15-20 min; 2.) 1 h. 4: 87 percent / sodium methoxide / CH2Cl2; methanol / 1 h / Ambient temperature View Scheme

1: 1.) potassium iodide; 2.) lead tetraacetate / 1.) glacial CH3COOH, 60 dec C, 15-20 min; 2.) 1 h. 2: 87 percent / sodium methoxide / CH2Cl2; methanol / 1 h / Ambient temperature View Scheme