3-氨基-2,5-二甲基吡嗪合成路线 （共 6 条）
反应条件
ammonia; copper in water T=150°C; 48 h; Autoclave;
参考文献
Sunovion Pharmaceuticals Inc.
Patent: US2012/178748 A1, 2012 ;
Location in patent: Page/Page column 37 ;
US 20120178748 A1
反应条件
sodium amide in N,N-dimethyl-aniline T=170°C; 1 h;
参考文献
Sunovion Pharmaceuticals Inc.
Patent: US2012/178748 A1, 2012 ;
Location in patent: Page/Page column 41 ;
US 20120178748 A1
反应条件
hydrogenchloride in methanol; ethyl acetate
参考文献
Keegan, Kathleen S.; Kesicki, Edward A.; Gaudino, John Joseph; Cook, Adam Wade; Cowen, Scott Douglas; Burgess, Laurence Edward
Patent: US2003/69284 A1, 2003 ;
US 20030069284 A1
反应条件
hydrogenchloride; tin(ll) chloride in methanol T=60°C; 3.5 h;
参考文献
Sato; Matsuura; Miwa
Synthesis, 1994 , # 9 p. 931 - 934
反应条件
iodine in dimethyl sulfoxide
T=80°C; 1.5 h;
参考文献
Jovanovic, Misa V.
Heterocycles, 1984 , vol. 22, # 5 p. 1195 - 1210
反应条件
2: aqueous HCl
View Scheme
参考文献
Joiner; Spoerri
Journal of the American Chemical Society, 1941 , vol. 63, p. 1929
