(3aR,6aR)-六氢环戊并[b]吡咯-2(1H)-酮合成路线 （共 5 条）
反应条件
hydrogenchloride in methanol; water T=20°C; 1 h;
参考文献
F. HOFFMANN-LA ROCHE AG; HOFFMANN-LA ROCHE INC.; JAESCHKE, Georg; LINDEMANN, Lothar; STADLER, Heinz; VIEIRA, Eric
Patent: WO2014/12851 A1, 2014 ;
Location in patent: Page/Page column 7; 14 ;
反应条件
sodium hydroxide 2 h; Heatingor conc. NH3;
参考文献
Omar; Frahm
Archiv der Pharmazie, 1990 , vol. 323, # 11 p. 923 - 928
反应条件
1: 1,8-diazabicyclo[5.4.0]undec-7-ene / toluene / 2 h / |Reflux 2: hydrogenchloride / methanol; water / 1 h / 20 °C View Scheme
参考文献
F. HOFFMANN-LA ROCHE AG; HOFFMANN-LA ROCHE INC.; JAESCHKE, Georg; LINDEMANN, Lothar; STADLER, Heinz; VIEIRA, Eric
Patent: WO2014/12851 A1, 2014 ;
反应条件
1: 3 h / 130 °C / |Heating 2: boron trifluoride diethyl etherate; triethylsilane / dichloromethane / 20 h / 50 °C 3: p-toluenesulfonyl chloride; pyridine / dichloromethane / 0.92 h / 0 - 20 °C 4: 1,8-diazabicyclo[5.4.0]undec-7-ene / toluene / 2 h / |Reflux 5: hydrogenchloride / methanol; water / 1 h / 20 °C View Scheme
参考文献
F. HOFFMANN-LA ROCHE AG; HOFFMANN-LA ROCHE INC.; JAESCHKE, Georg; LINDEMANN, Lothar; STADLER, Heinz; VIEIRA, Eric
Patent: WO2014/12851 A1, 2014 ;
反应条件
1: boron trifluoride diethyl etherate; triethylsilane / dichloromethane / 20 h / 50 °C 2: p-toluenesulfonyl chloride; pyridine / dichloromethane / 0.92 h / 0 - 20 °C 3: 1,8-diazabicyclo[5.4.0]undec-7-ene / toluene / 2 h / |Reflux 4: hydrogenchloride / methanol; water / 1 h / 20 °C View Scheme
参考文献
F. HOFFMANN-LA ROCHE AG; HOFFMANN-LA ROCHE INC.; JAESCHKE, Georg; LINDEMANN, Lothar; STADLER, Heinz; VIEIRA, Eric
Patent: WO2014/12851 A1, 2014 ;
