1: 91 percent / H2O, conc.H2SO4 / 4 h / Heating 2: 84 percent / 3 M aq.HCl / ethanol / 1 h / Heating; Dimroth rearrangement of other aminobenzothiazinones; reaction also in 0.25 M aq.NaOH View Scheme

3-(cyclohexylamino)propanesulfonic acid buffer; water in acetonitrile T=25°C; pH 9.0-11.5; also with chymotrypsin; Rate constant;

sulfuric acid; water 4 h; Heating;