4-硝基-1H-吡咯-2-甲酸甲酯合成路线 （共 14 条）
反应条件
1: T=20°C; 2 h; 2: With sulfuric acid in methanol; water
参考文献
BIOCRYST PHARMACEUTICALS, INC.; BABU, Yarlagadda, S.; KOTIAN, Pravin, L.; WU, Minwan
Patent: WO2011/150356 A1, 2011 ;
Location in patent: Page/Page column 93 ;
WO 2011/150356 A1
反应条件
in methanol T=20°C; 2 h;
参考文献
BIOCRYST PHARMACEUTICALS, INC.; BABU, Yarlagadda S.; KOTIAN, Pravin L.; KUMAR, V. Satish; WU, Minwan; LIN, Tsu-Hsing
Patent: WO2011/14817 A1, 2011 ;
Location in patent: Page/Page column 104 ;
WO 2011/014817 A1
反应条件
sodium hydroxide in ethanol; water T=50°C; 0.5 h;
参考文献
Hotzel, Christian; Marotto, Annalisa; Pindur, Ulf
European Journal of Medicinal Chemistry, 2002 , vol. 37, # 5 p. 367 - 378
反应条件
4-(N,N-dimethlyamino)pyridine T=70°C;
参考文献
Lautru, Sylvie; Song, Lijiang; Demange, Luc; Lombes, Thomas; Galons, Herve; Challis, Gregory L.; Pernodet, Jean-Luc
Angewandte Chemie - International Edition, 2012 , vol. 51, # 30 p. 7454 - 7458
反应条件
sodium hydroxide in methanol T=50°C; Cyclization;
参考文献
Dudouit, Fabienne; Goossens, Jean-Francois; Houssin, Raymond; Henichart, Jean-Pierre; Colson, Pierre; Houssier, Claude; Gelus, Nathalie; Bailly, Christian
Bioorganic and Medicinal Chemistry Letters, 2000 , vol. 10, # 6 p. 553 - 557
反应条件
nitric acid in acetic anhydride T=-15°C;
参考文献
Tetrahedron Letters, , vol. 46, # 42 p. 7101 - 7105
反应条件
1: 70 percent / HNO3; Ac2O / 12 h / -40 - 20 °C 2: 88 percent / DMAP / 10 h / 60 °C View Scheme
参考文献
Organic and Biomolecular Chemistry, , vol. 1, # 19 p. 3327 - 3342
反应条件
sodium hydroxide in methanol T=60°C; 20 h;
参考文献
Kumar, Rohtash; Lown, J. William
Organic and Biomolecular Chemistry, 2003 , vol. 1, # 19 p. 3327 - 3342
