4-硝基-1H-吡咯-2-甲酸甲酯合成路线 （共 14 条）
反应条件
1: methyl 4-nitro-2-pyrrolecarboxylate With potassium in tetrahydrofuran 1 h; Heating; 2: methyl iodide in tetrahydrofuran 1 h; Heating;
参考文献
European Journal of Medicinal Chemistry, , vol. 37, # 5 p. 367 - 378
反应条件
1: 55 percent / NaH / dimethylformamide / 20 °C 2: 91 percent / aq. NaOH / tetrahydrofuran View Scheme
参考文献
Dudouit, Fabienne; Goossens, Jean-Francois; Houssin, Raymond; Henichart, Jean-Pierre; Colson, Pierre; Houssier, Claude; Gelus, Nathalie; Bailly, Christian
Bioorganic and Medicinal Chemistry Letters, 2000 , vol. 10, # 6 p. 553 - 557
反应条件
1.1: potassium / tetrahydrofuran / 1 h / Heating
1.2: 72 percent / tetrahydrofuran / 1 h / Heating
2.1: H2 / Pd/C / methanol / 3 h / 20 °C / 760 Torr
View Scheme
参考文献
Hotzel, Christian; Marotto, Annalisa; Pindur, Ulf
European Journal of Medicinal Chemistry, 2002 , vol. 37, # 5 p. 367 - 378
反应条件
1: 80 percent / aq. NaOH / methanol / 20 h / 60 °C
2: 83 percent / H2SO4 / diethyl ether / 36 h / 20 °C
View Scheme
参考文献
Kumar, Rohtash; Lown, J. William
Organic and Biomolecular Chemistry, 2003 , vol. 1, # 19 p. 3327 - 3342
