4-硝基-1-甲基吡咯-2-羧酸甲酯合成路线 （共 29 条）
参考文献
Organic and biomolecular chemistry, , vol. 1, # 15 p. 2630 - 2647
反应条件
1: With sodium methylate in methanol T=20°C; 0.5 h; 2: With sulfuric acid in methanol Heating / reflux;
参考文献
WO2004/99131 A2, ;
Page 60 ;
反应条件
sulfuric acid 12 h; Heating;
参考文献
European Journal of Organic Chemistry, , # 21 p. 3604 - 3615
反应条件
1: methyl 4-nitro-2-pyrrolecarboxylate With potassium in tetrahydrofuran 1 h; Heating; 2: methyl iodide in tetrahydrofuran 1 h; Heating;
参考文献
European Journal of Medicinal Chemistry, , vol. 37, # 5 p. 367 - 378
反应条件
1: 1.2 kg / diethyl ether / 3 h 2: HNO3, Ac2O / -40 - 20 °C 3: 47 percent / NaOMe / 2 h / Ambient temperature View Scheme
参考文献
Journal of the American Chemical Society, , vol. 118, # 26 p. 6141 - 6146
反应条件
1: 40 percent / HNO3 / acetic anhydride / -25 °C 2: 95 percent / H2SO4 / 12 h / Heating View Scheme
参考文献
European Journal of Organic Chemistry, , # 21 p. 3604 - 3615
反应条件
1: HNO3, Ac2O / -40 - 20 °C 2: 47 percent / NaOMe / 2 h / Ambient temperature View Scheme
参考文献
Journal of the American Chemical Society, , vol. 118, # 26 p. 6141 - 6146
反应条件
nitric acid; acetic anhydride 1) -20 deg C, 6 h; 2) room temperature, 4 h;
参考文献
Journal of Pharmaceutical Sciences, , vol. 78, # 11 p. 910 - 917
参考文献
Journal of Organic Chemistry, , vol. 77, # 23 p. 10870 - 10881
反应条件
sulfuric acid; nitric acid; acetic anhydride 2.) methanol, reflux, 12 h; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Journal of Medicinal Chemistry, , vol. 32, # 5 p. 1074 - 1083
