1-甲基-4-硝基吡咯-2-羧酸合成路线 （共 25 条）
反应条件
1: With sodium hydroxide in water T=20°C; 5 h; 2: With hydrogenchloride in water pH=3;
参考文献
PHARMACIA CORPORATION
Patent: WO2004/99131 A2, 2004 ;
Location in patent: Page 55 ;
反应条件
nitric acid; acetic anhydride 1.) a) -15 deg C, 0.5 h, b) RT, 20 min;
参考文献
Lown, J. William; Krowicki, Krzysztof
Journal of Organic Chemistry, 1985 , vol. 50, # 20 p. 3774 - 3779
参考文献
Debart; Perigaud; Gosselin; Mrani; Rayner; Le Ber; Auclair; Balzarini; De Clercq; Paoletti; Imbach
Journal of Medicinal Chemistry, 1989 , vol. 32, # 5 p. 1074 - 1083
反应条件
sodium hydroxide in 1,4-dioxane; ethanol 2 h; Ambient temperature;
参考文献
Otsuka; Masuda; Haupt; Ohno; Shiraki; Sugiura; Maeda
Journal of the American Chemical Society, 1990 , vol. 112, # 2 p. 838 - 845
反应条件
sulfuric acid in methanol; water
参考文献
California Institute of Technology
Patent: US6090947 A1, 2000 ;
反应条件
1: ethanol; sodium methylate 2: ethanol; aqueous NaOH View Scheme
参考文献
Weiss et al.
Journal of the American Chemical Society, 1957 , vol. 79, p. 1266
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Am. Cyanamid Co.
Patent: US2785181 , 1954 ;
反应条件
1: 55 percent / NaH / dimethylformamide / 20 °C 2: 91 percent / aq. NaOH / tetrahydrofuran View Scheme
参考文献
Dudouit, Fabienne; Goossens, Jean-Francois; Houssin, Raymond; Henichart, Jean-Pierre; Colson, Pierre; Houssier, Claude; Gelus, Nathalie; Bailly, Christian
Bioorganic and Medicinal Chemistry Letters, 2000 , vol. 10, # 6 p. 553 - 557
反应条件
1: acetic acid anhydride; nitric acid 2: aqueous NaOCl; aqueous NaOH View Scheme
参考文献
Anderson
Canadian Journal of Chemistry, 1957 , vol. 35, p. 21,26
反应条件
thionyl chloride 2 - 4 h; Heating / reflux; Product distribution / selectivity;
参考文献
UNIVERSITY OF STRATHCLYDE
Patent: WO2008/38018 A1, 2008 ;
Location in patent: Page/Page column 41; 46 ;
反应条件
1: H2, acetic acid / Pd/C / methanol / 16 h / 3000.24 Torr 2: aq. Na2CO3 / acetone / 12 h View Scheme
参考文献
Koenig, Burkhard; Roedel, Martin
Synthetic Communications, 1999 , vol. 29, # 6 p. 943 - 949
