反应条件
1: C21H31N2O5Pol With trifluoroacetic acid in dichloromethane 0.5 h; solid phase reaction; 2: N-Boc-L-His(Tos)-OH With benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine in 1-methyl-pyrrolidin-2-one; dimethyl sulfoxide 3 h; solid phase reaction; 3: 1-(tert-butoxycarbonyl)-L-proline; t-Boc-L-valine; (2S,3S)-2-(tert-butoxycarbonylamino)-3-methylpentanoic acid; N-tert-butoxycarbonyl-L-phenylalanine; boc-Ng-tosyl-L-arginine; (2S)-3-cyclohexyloxycarbonyl-2-t-butoxycarbonylaminopropanoic acid; Boc-L-tyrosine(2-Br-Z)-OH; N-Boc-L-His(Tos)-OH Further stages;
参考文献
Nakaie, Clovis R.; Oliveira, Eliandre; Vicente, Eduardo F.; Jubilut, Guita N.; Souza, Sinval E.G.; Marchetto, Reinaldo; Cilli, Eduardo M.
Bioorganic Chemistry, 2011 , vol. 39, # 2 p. 101 - 109
