反应条件
1: 2-(S)-piperazine carboxylic acid; N-(benzyloxycarbonyloxy)-succinimide With sodium hydroxide in 1,4-dioxane; water T=20°C; pH=9.5 - 11; 0.75 h; 2: 2-(tert-butoxycarbonyloxyimino)-2-phenylacetonitrile in 1,4-dioxane; water T=20°C; pH=9.5; 17 h; 3: With hydrogenchloride in 1,4-dioxane; water pH=2;
参考文献
BIKAM PHARMACEUTICALS, INC.; GARVEY, David, S.; LAROSA, Gregory, J.; GREENWOOD, Jeremy, Robert; BREWER, Mark, L.; QUACH, Tan; COTE, Jamie, B.; BERMAN, Judd
Patent: WO2010/147653 A1, 2010 ;
Location in patent: Page/Page column 117-118 ;