1: (R)-3-piperidinecarboxylic acid ethyl ester (+)-tartrate With sodium hydroxide in water T=5°C; 2: N-(benzyloxycarbonyloxy)-succinimide in tetrahydrofuran; water T=5 - 20°C; 1 h; 3: With hydrogenchloride in water pH=2 - 3;
参考文献
NOVO NORDISK A/S
Patent: WO2004/33455 A2, 2004 ;
Location in patent: Page 26 ;
WO 2004/033455 A2