3-甲基-CBS-氧硼啶合成路线 （共 731 条）
参考文献
Journal fuer Praktische Chemie (Leipzig), , vol. <2>128, p. 153,169,170
反应条件
in tetrahydrofuran T=-5 - 20°C; Heating / reflux;
参考文献
BOEHRINGER INGELHEIM PHARMACEUTICALS, INC.
Patent: WO2004/14870 A1, 2004 ;
Location in patent: Page 44-46 ;
反应条件
1: trifluoroacetic acid With bromine; magnesium in diethyl ether T=20°C; Metallation; 1.5 h; 2: 4-methoxyphenyl magnesium bromide in diethyl ether Grignard reaction; 1 h; Heating;
参考文献
Uno, Hidemitsu; Nibu, Nobumasa; Misobe, Noboru
Bulletin of the Chemical Society of Japan, 1999 , vol. 72, # 6 p. 1365 - 1375
反应条件
in tetrahydrofuran T=-78°C; 1 h;
参考文献
Konno, Tsutomu; Takehana, Tsuyoshi; Mishima, Makoto; Ishihara, Takashi
Journal of Organic Chemistry, 2006 , vol. 71, # 9 p. 3545 - 3550
反应条件
hydrogenchloride in tetrahydrofuran
参考文献
Hoechst Schering Agrevo
Patent: US6197729 B1, 2001 ;
反应条件
air in dichloromethane T=0°C; Schlenk technique;
参考文献
Goto, Akihiro; Otake, Kazuki; Kubo, Ozora; Sawama, Yoshinari; Maegawa, Tomohiro; Fujioka, Hiromichi
Chemistry - A European Journal, 2012 , vol. 18, # 36 p. 11423 - 11432
反应条件
((C6H4)(PPh2)(NCHPhP(O)Ph2))NiCl in diethyl ether T=25°C; Kumada cross-coupling; 12 h; Inert atmosphere;
参考文献
Liu, Ning; Wang, Zhong-Xia
Journal of Organic Chemistry, 2011 , vol. 76, # 24 p. 10031 - 10038
反应条件
1.1: tetrahydrofuran / 3 h / 0 °C / |Inert atmosphere 1.2: 20 °C / |Inert atmosphere 2.1: 2,2'-azo-bisisobutyronitrile; tris-(trimethylsilyl)silane / toluene / 0.23 h / 110 °C / |Inert atmosphere View Scheme
参考文献
Kumar, Dhananjay; Mishra, Bhuwan B.; Tiwari, Vinod K.
Journal of Organic Chemistry, 2014 , vol. 79, # 1 p. 251 - 266
反应条件
1: 4-chlorobenzoic acid methyl ester With Co(acetylacetonate)3 in tetrahydrofuran; 1-methyl-pyrrolidin-2-one T=30°C; 1 h; 2: 4-methoxyphenyl magnesium bromide in tetrahydrofuran; 1-methyl-pyrrolidin-2-one T=30°C; 0.000555556 h;
参考文献
Guelak, Samet; Stepanek, Ondrej; Malberg, Jennifer; Rad, Babak Rezaei; Kotora, Martin; Wolf, Robert; Jacobi Von Wangelin, Axel
Chemical Science, 2013 , vol. 4, # 2 p. 776 - 784
反应条件
1: 4-methoxyphenyl magnesium bromide With zinc dibromide in tetrahydrofuran; ethylpyrrolidin-2-one; 1- Inert atmosphereSchlenk tubeCooling; 2: para-bromobenzonitrile With 4-(N,N-dimethlyamino)pyridine; phosphonic acid diethyl ester; nickel dichloride in tetrahydrofuran; ethylpyrrolidin-2-one; 1- T=50°C; 72 h; Schlenk tubeInert atmosphere; 3: With ammonium chloride in tetrahydrofuran; ethylpyrrolidin-2-one; 1-
参考文献
US2010/184977 A1, ;
Page/Page column 7-8 ;
