3-甲基-CBS-氧硼啶合成路线 （共 731 条）
反应条件
1: tetrahydrofuran / 0 - 20 °C / Inert atmosphere 2: pyridinium chlorochromate / dichloromethane / 20 °C / Molecular sieve View Scheme
参考文献
TFCHEM; DELIENCOURT-GODEFROY, Geraldine; LOPES, Lenaig
Patent: WO2012/160218 A1, 2012 ;
WO 2012/160218 A1
参考文献
Bennett,J.G.; Bunce,S.C.
Journal of Organic Chemistry, 1960 , vol. 25, p. 73 - 79
反应条件
1: tetrahydrofuran / 2 h 2: HCl gas / tetrahydrofuran; cyclohexane View Scheme
参考文献
RajanBabu; Ayers, Timothy A.; Halliday, Gary A.; You, Kimberly K.; Calabrese, Joseph C.
Journal of Organic Chemistry, 1997 , vol. 62, # 17 p. 6012 - 6025
反应条件
diethyl ether und anschliessenden Hydrolyse;
参考文献
Koenig; Scharrnbeck
Journal fuer Praktische Chemie (Leipzig), 1930 , vol. <2>128, p. 153,169,170
反应条件
1: in tetrahydrofuran T=0°C; Grignard reaction; 3.5 h; Inert atmosphere; 2: With potassium hydroxide in methanol 24 h; Reflux;
参考文献
Fleischer, Ivana; Pfaltz, Andreas
Chemistry - A European Journal, 2010 , vol. 16, # 1 p. 95 - 99
反应条件
1: diethyl ether / Erhitzen des Reaktionsprodukts mit Essigsaeure, Acetanhydrid und Naphthalin-2-sulfonsaeure und anschliessend mit Schwefel 2: KMnO4 3: aqueous HBr; acetic acid View Scheme
参考文献
Journal of the American Chemical Society, , vol. 75, p. 4969,4972
反应条件
in tetrahydrofuran; dichloromethane 1.) -78 deg C, 30 min, 2.) 0 deg C, 30 min;
参考文献
Miller, R. D.; Renaldo, A. F.; Ito, H.
Journal of Organic Chemistry, 1988 , vol. 53, # 23 p. 5571 - 5573
反应条件
in tetrahydrofuran 1 h; Heating;
参考文献
Komoto, Teruo; Hirota, Hiroyuki; Otsuka, Mari; Kotake, Jiro; Hasegawa, Susumu; Koya, Hidehiko; Sato, Susumu; Sakamoto, Takao
Chemical and Pharmaceutical Bulletin, 2000 , vol. 48, # 12 p. 1978 - 1985
反应条件
copper(I) bromide; lithium bromide in tetrahydrofuran T=0°C; 0.25 h;
参考文献
Babudri, Francesco; Fiandanese, Vito; Marchese, Giuseppe; Punzi, Angela
Tetrahedron Letters, 1995 , vol. 36, # 40 p. 7305 - 7308
反应条件
1: With nickel dichloride T=20°C; Kumada-Tamao-Corriu cross-coupling; 3 h; 2: With water; ammonium chloride
参考文献
Shibahara, Fumitoshi; Yamaguchi, Eiji; Kitagawa, Asumi; Imai, Akio; Murai, Toshiaki
Tetrahedron, 2009 , vol. 65, # 26 p. 5062 - 5073
