3-甲基-CBS-氧硼啶合成路线 （共 731 条）
反应条件
2: concentrated sulfuric acid; glacial acetic acid / 0 °C View Scheme
参考文献
Cristol; Harms
Journal of the American Chemical Society, 1949 , vol. 71, p. 2875,4167
反应条件
1: cadmium chloride; diethyl ether; benzene / Erwaermen der vom Aether befreiten Reaktionsloesung mit Bernsteinsaeure-methylester-chlorid 2: potassium hydroxide; diethylene glycol; hydrazine hydrate / 200 °C / Erwaermen des Reaktionsprodukts mit wss. Natronlauge und Dimethylsulfat View Scheme
参考文献
Dauben; Tanabe
Journal of the American Chemical Society, 1949 , vol. 71, p. 2877
反应条件
diethyl ether; hydrogen; phosphorus trichoride
参考文献
Mann; Chaplin
Journal of the Chemical Society, 1937 , p. 527,530
参考文献
Swain et al.
Journal of the American Chemical Society, 1955 , vol. 77, p. 4681
反应条件
1: 4-methoxyphenyl magnesium bromide With N,N,N',N,-tetramethylethylenediamine; zinc(II) chloride in tetrahydrofuran T=80°C; 0.25 h; microwave irradiation; 2: 4-bromo-benzaldehyde With bis-triphenylphosphine-palladium(II) chloride in tetrahydrofuran T=20°C; Negishi cross-coupling; 0.0833333 h;
参考文献
Tetrahedron, , vol. 61, # 47 p. 11168 - 11176
反应条件
in tetrahydrofuran T=1°C; 0.0833333 h;
参考文献
Mutule, Ilga; Suna, Edgars
Tetrahedron, 2005 , vol. 61, # 47 p. 11168 - 11176
反应条件
in tetrahydrofuran T=0 - 20°C;
参考文献
Hudkins, Robert L.; Aimone, Lisa D.; Dandu, Reddeppa Reddy; Dunn, Derek; Gruner, John A.; Huang, Zeqi; Josef, Kurt A.; Lyons, Jacquelyn A.; Mathiasen, Joanne R.; Tao, Ming; Zulli, Allison L.; Raddatz, Rita
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 1 p. 194 - 198
反应条件
1: 1.) 2,3-dichloro-5,6-dicyano-p-benzoquinone / 1.) ether, reflux, 3 h, 2.) CH2Cl2, reflux, 3 h 2: 1.) DIBAH, 2.) Jones reagent / 1.) toluene, -78 deg C, 4 h, 2.) acetone, room temp., 15 min 3: 70percent t-butyl-hydroperoxide, 40percent benzyltrimethylammonium hydroxide / benzene / Ambient temperature 4: p-toluenesulfonic acid / CH2Cl2 / 2 h 5: 100 percent / boron tribromide / CH2Cl2 / 0.25 h View Scheme
参考文献
Luis; Fletcher; Echeverri; Grillo
Tetrahedron, 1994 , vol. 50, # 37 p. 10963 - 10970
反应条件
dilithium tetrachlorocuprate in tetrahydrofuran 12 h; Ambient temperature;
参考文献
Kadkhodayan, Miryam; Singleton, Terry; Heldrich, F. J.
Synthetic Communications, 1984 , vol. 14, # 8 p. 707 - 712
反应条件
in diethyl ether T=-78°C;
参考文献
Creary, Xavier
Journal of Organic Chemistry, 1980 , vol. 45, # 13 p. 2727 - 2729
