3-甲基-CBS-氧硼啶合成路线 （共 731 条）
反应条件
1: With 1-[2-(diphenylphosphino)phenyl]ethanol; bis(acetylacetonate)nickel(II) in diethyl ether 12 h; 2: With methanol in diethyl ether Product distribution / selectivity;
参考文献
THE UNIVERSITY OF TOKYO
Patent: WO2006/85628 A1, 2006 ;
Location in patent: Page/Page column 32-34 ;
反应条件
2: tin; aq.-ethanolic HCl; CuSO4
3: sodium-amalgam
View Scheme
参考文献
Jenkins
Journal of the American Chemical Society, 1932 , vol. 54, p. 1155,1161
参考文献
Baciocchi, Enrico; Bietti, Massimo; Putignani, Lorenza; Steenken, Steen
Journal of the American Chemical Society, 1996 , vol. 118, # 25 p. 5952 - 5960
反应条件
1: 4-methoxyphenyl magnesium bromide With zinc(II) chloride in tetrahydrofuran
T=-20°C; 0.25 h; Inert atmosphere;
2: With methyl-magnesium chloride in tetrahydrofuran
T=-20°C; 0.25 h; Inert atmosphere;
3: n-amyl iodide With triphenylphosphine; nickel dichloride in tetrahydrofuran
T=0 - 20°C; 1 h; Inert atmosphere; regioselective reaction;
参考文献
Pekel, Oezgen Oemuer; Erdik, Ender
Tetrahedron Letters, 2011 , vol. 52, # 52 p. 7087 - 7090
反应条件
N-nitroso-diphenylamine in tetrahydrofuran
T=-15 - 20°C; 1.5 h;
参考文献
Cardellini; Greci; Tosi
Synthetic Communications, 1992 , vol. 22, # 2 p. 201 - 207
反应条件
1: diethyl ether; benzene / 20 °C
3: palladium/charcoal / 280 - 320 °C
4: concentrated aqueous HBr; glacial acetic acid
5: palladium/charcoal / 340 °C
View Scheme
参考文献
Orchin
Journal of the American Chemical Society, 1948 , vol. 70, p. 495
反应条件
3: HCl; aqueous acetone
View Scheme
参考文献
Fuson et al.
Journal of the American Chemical Society, 1956 , vol. 78, p. 6064
参考文献
Nachtsheim, Corina M.; Frahm, August W.
Archiv der Pharmazie (Weinheim, Germany), 1989 , vol. 322, p. 187 - 197
反应条件
1: CuBr*Me2S / tetrahydrofuran / 0 °C
2: aq. Dess-Martin periodinane / CH2Cl2 / 20 °C
View Scheme
参考文献
Collins, David J.; Molinski, Tadeusz F.; Sjoevall, Jan
Australian Journal of Chemistry, 1983 , vol. 36, # 2 p. 361 - 370
反应条件
CoCl2 in tetrahydrofuran; diethyl ether
T=-40°C; 12 h;
参考文献
Korn, Tobias J.; Schade, Matthias A.; Cheemala, Murthy N.; Wirth, Stefan; Guevara, Simon A.; Cahiez, Gerard; Knochel, Paul
Synthesis, 2006 , # 21 p. 3547 - 3574
