3-甲基-CBS-氧硼啶合成路线 （共 731 条）
参考文献
Fuson; Gaertner
Journal of Organic Chemistry, 1948 , vol. 13, p. 496,499
反应条件
in tetrahydrofuran
Grignard reaction; 12 h; Heating;
参考文献
Lubczyk, Veronika; Bachmann, Helmut; Gust, Ronald
Journal of Medicinal Chemistry, 2003 , vol. 46, # 8 p. 1484 - 1491
参考文献
Carter; Hey
Journal of the Chemical Society, 1948 , p. 147
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Merrell Co.
Patent: US2430891 , 1941 ;
反应条件
1.1: tetrahydrofuran / 0 - 20 °C / Inert atmosphere
2.1: pyridinium chlorochromate / dichloromethane / 20 °C / Molecular sieve
3.1: BBr3*DMSO / dichloromethane / 3 h / 0 °C
3.2: 0.17 h / cooling with ice
View Scheme
参考文献
TFCHEM; DELIENCOURT-GODEFROY, Geraldine; LOPES, Lenaig
Patent: WO2012/160218 A1, 2012 ;
WO 2012/160218 A1
反应条件
1: 1-chloro-3-methylbenzene With HASPO; Ni(acac)2 in tetrahydrofuran
T=20°C; 0.0833333 h;
2: 4-methoxyphenyl magnesium bromide in tetrahydrofuran
T=20°C; Kumada cross-copling; 4 h;
参考文献
Ackermann, Lutz; Born, Robert; Spatz, Julia H.; Meyer, Daniel
Angewandte Chemie - International Edition, 2005 , vol. 44, # 44 p. 7216 - 7219
反应条件
tris(dibenzylideneacetone)dipalladium(0) chloroform complex; 3-tert-butyl-5-methyl-1-(2-(diphenylphosphino)phenyl)-1H-pyrazole in tetrahydrofuran; toluene
T=55°C; Kumada coupling; 10 h; Inert atmosphere;
参考文献
Pal, Anwesha; Ghosh, Raju; Adarsh; Sarkar, Amitabha
Tetrahedron, 2010 , vol. 66, # 29 p. 5451 - 5458
反应条件
bis(carbene)-derived nickel(II)-pincer complex in tetrahydrofuran
T=20°C; Grignard coupling reaction; 96 h;
参考文献
Inamoto, Kiyofumi; Kuroda, Jun-Ichi; Sakamoto, Takao; Hiroya, Kou
Synthesis, 2007 , # 18 p. 2853 - 2861
反应条件
1.1: 73 percent / diethyl ether / 0 - 20 °C
2.1: TBAF / tetrahydrofuran
2.2: 85 percent / TBAF; (t-Bu)3P / [(allyl)PdCl]2 / tetrahydrofuran / 1 h / Heating
View Scheme
参考文献
Denmark, Scott E.; Wu, Zhicai
Organic Letters, 1999 , vol. 1, # 9 p. 1495 - 1498
反应条件
diethyl ether
Erhitzen des Reaktionsprodukts mit Essigsaeure, Acetanhydrid und Naphthalin-2-sulfonsaeure und anschliessend mit Schwefel;
参考文献
Dauben; Tanabe
Journal of the American Chemical Society, 1953 , vol. 75, p. 4969,4972
反应条件
2: chromic acid; glacial acetic acid
View Scheme
参考文献
Lagrave
Annales de Chimie (Cachan, France), 1927 , vol. <10> 8, p. 392
