3-甲基-CBS-氧硼啶合成路线 （共 731 条）
反应条件
1: diethyl ether
2: aqueous HBr
View Scheme
参考文献
Welsh; Drake
Journal of the American Chemical Society, 1938 , vol. 60, p. 59,61
反应条件
1: diethyl ether
2: amidosulfuric acid / 10 - 20 Torr
View Scheme
参考文献
Merrell Co.
Patent: US2430891 , 1941 ;
参考文献
Ando
Yuki Gosei Kagaku Kyokaishi, 1959 , vol. 17, p. 339,340, 777, 779
Chem.Abstr., 1959 , p. 17971,1960 4492
参考文献
Ando
Yuki Gosei Kagaku Kyokaishi, 1959 , vol. 17, p. 777,779
Chem.Abstr., 1960 , p. 4492
反应条件
1: N-cyclohexyl-4-(methoxycarbonyl)benzamide With 2-fluoro-pyridine; trifluoromethylsulfonic anhydride in dichloromethane
T=-78 - 0°C; Inert atmosphere;
2: 4-methoxyphenyl magnesium bromide in dichloromethane
T=0°C; 0.416667 h; Inert atmosphere;
3: With hydrogenchloride; water in tetrahydrofuran; dichloromethane
T=65°C; 3 h; Inert atmosphere; chemoselective reaction;
参考文献
Bechara, William S.; Pelletier, Guillaume; Charette, Andre B.
Nature Chemistry, 2012 , vol. 4, # 3 p. 228 - 234
反应条件
1: diethyl ether
2: pentane; SO2Cl2
View Scheme
参考文献
Bordwell; Pitt
Journal of the American Chemical Society, 1955 , vol. 77, p. 572,576
反应条件
1-ethyl-2-pyrrolidinone; 4-(N,N-dimethlyamino)pyridine; phosphonic acid diethyl ester; nickel dichloride; zinc dibromide in tetrahydrofuran
T=20°C; 2 h;
参考文献
knochel, Paul; Gavriushin, Andrei; Kofink, Christiane Charlotte; Manolikakes, Georg
Patent: US2010/184977 A1, 2010 ;
Location in patent: Page/Page column 3-4 ;
反应条件
1: 4-methoxyphenyl magnesium bromide With ZnCl2*TMEDA in tetrahydrofuran
T=20°C;
2: 4-Iodo-butyronitrile With iron(III) chloride in tetrahydrofuran
T=50°C; 0.5 h;
参考文献
Nakamura, Masaharu; Ito, Shingo; Matsuo, Keiko; Nakamura, Eiichi
Synlett, 2005 , # 11 art. no. Y00305ST, p. 1794 - 1798
反应条件
1: 41 percent / diethyl ether / 2 h / Heating
2: 93 percent / sodium bisulfate / 0.33 h / 190 °C
3: N-chlorosuccinimide, hexamethylphosphoramide / 16 h / 100 °C
View Scheme
参考文献
Johnson; Phillipou; Seaborn
Australian Journal of Chemistry, 1980 , vol. 33, # 2 p. 461 - 464
反应条件
1: (4-methoxyphenyl)methanol With n-butyllithium; chloro-diphenylphosphine in tetrahydrofuran
2: With methyl iodide in tetrahydrofuran
T=20°C; 1 h;
3: 4-methoxyphenyl magnesium bromide in tetrahydrofuran
T=20°C; 1 h;
参考文献
Shintou, Taichi; Kikuchi, Wataru; Mukaiyama, Teruaki
Chemistry Letters, 2003 , vol. 32, # 8 p. 676 - 677
