3-甲基-CBS-氧硼啶合成路线 （共 731 条）
反应条件
PinP(O)H; [Pd(dibenzylideneacetone)2] in tetrahydrofuran; 1,4-dioxane
T=80°C; Kumada cross-coupling reaction; 22 h;
参考文献
Ackermann, Lutz; Althammer, Andreas
Organic Letters, 2006 , vol. 8, # 16 p. 3457 - 3460
反应条件
tris(dibenzylideneacetone)dipalladium(0) chloroform complex; 3-tert-butyl-5-methyl-1-(2-(diphenylphosphino)phenyl)-1H-pyrazole in tetrahydrofuran; toluene
T=55°C; Kumada coupling; 10 h; Inert atmosphere;
参考文献
Pal, Anwesha; Ghosh, Raju; Adarsh; Sarkar, Amitabha
Tetrahedron, 2010 , vol. 66, # 29 p. 5451 - 5458
反应条件
bis-triphenylphosphine-palladium(II) chloride in tetrahydrofuran
T=20°C; 4 h; Inert atmosphere;
参考文献
Reeves, Jonathan T.; Fandrick, Daniel R.; Tan, Zhulin; Song, Jinhua J.; Lee, Heewon; Yee, Nathan K.; Senanayake, Chris H.
Organic Letters, 2010 , vol. 12, # 19 p. 4388 - 4391
反应条件
1.1: 73 percent / diethyl ether / 0 - 20 °C
2.1: TBAF / tetrahydrofuran
2.2: 89 percent / TBAF; (t-Bu)3P / [(allyl)PdCl]2 / tetrahydrofuran / 3 h / Heating
View Scheme
参考文献
Khastagir; Bhattacharyya
Journal of the Indian Chemical Society, 1949 , vol. 26, p. 296,299
反应条件
1: diethyl ether
3: KOH; triethylene glycol / Erhitzen auf Siedetemperatur
4: nickel-aluminium-alloy; aqueous NaOH
View Scheme
参考文献
Miquel
Acta Chemica Scandinavica (1947-1973), 1958 , vol. 12, p. 274,280
反应条件
1: 80 percent
2: 40 percent / formic acid / 8 h / Heating
View Scheme
参考文献
Somers, J. B. M.; Couture, A.; Lablache-Combier, A.; Laarhoven, W. H.
Journal of the American Chemical Society, 1985 , vol. 107, # 5 p. 1387 - 1394
反应条件
1: 77 percent / NiCl2(dppe) / tetrahydrofuran / 18 h / 20 °C
2: 76 percent / KMnO4 / 2-methyl-propan-2-ol; H2O / Heating
View Scheme
参考文献
Filosa, Rosanna; Peduto, Antonella; de Caprariis, Paolo; Saturnino, Carmela; Festa, Michela; Petrella, Antonello; Pau, Amedeo; Pinna, Gerard Aime; La Colla, Paolo; Busonera, Bernardetta; Loddo, Roberta
European Journal of Medicinal Chemistry, 2007 , vol. 42, # 3 p. 293 - 306
反应条件
1: 4-methoxyphenyl magnesium bromide With Et2AlBr in tetrahydrofuran
T=0 - 20°C; Inert atmosphere;
2: With titanium(IV) isopropylate; (S)-(minus;)-1,1'-bi-2-naphthol in toluene
T=0°C; 0.5 h; Inert atmosphere;
3: acetophenone Further stages;
参考文献
Zhou, Shuangliu; Wu, Kuo-Hui; Chen, Chien-An; Gau, Han-Mou
Journal of Organic Chemistry, 2009 , vol. 74, # 9 p. 3500 - 3505
参考文献
Merrell Co.
Patent: US2832786 , 1956 ;
反应条件
zinc(II) chloride in tetrahydrofuran
T=0 - 20°C; Inert atmosphere;
参考文献
Hirner, Sebastian; Somfai, Peter
Journal of Organic Chemistry, 2009 , vol. 74, # 20 p. 7798 - 7803
