3-甲基-CBS-氧硼啶合成路线 （共 731 条）
反应条件
1: diethyl ether; benzene / 20 °C
3: palladium/charcoal / 280 - 320 °C
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参考文献
Orchin
Journal of the American Chemical Society, 1948 , vol. 70, p. 495
反应条件
in tetrahydrofuran
T=23 - 60°C;
参考文献
PRESIDENT AND FELLOWS OF HARVARD COLLEGE; RITTER, Tobias; FURUYA, Takeru; TANG, Pingping
Patent: WO2010/59943 A2, 2010 ;
Location in patent: Page/Page column 32 ;
反应条件
in tetrahydrofuran
T=0 - 20°C;
参考文献
Nakao, Yoshiaki; Chen, Jinshui; Imanaka, Hidekazu; Hiyama, Tamejiro; Ichikawa, Yoshitaka; Duan, Wei-Liang; Shintani, Ryo; Hayashi, Tamio
Journal of the American Chemical Society, 2007 , vol. 129, # 29 p. 9137 - 9143
反应条件
diethyl ether; cadmium (II) chloride; benzene
Erwaermen der vom Aether befreiten Reaktionsloesung mit Bernsteinsaeure-methylester-chlorid;
参考文献
Dauben; Tanabe
Journal of the American Chemical Society, 1949 , vol. 71, p. 2877
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Dauben; Tilles
Journal of Organic Chemistry, 1950 , vol. 15, p. 785,787
反应条件
PinP(O)H; [Pd(dibenzylideneacetone)2] in tetrahydrofuran; 1,4-dioxane
T=80°C; Kumada cross-coupling reaction; 22 h;
参考文献
Ackermann, Lutz; Althammer, Andreas
Organic Letters, 2006 , vol. 8, # 16 p. 3457 - 3460
反应条件
C20H23BrN4Ni in tetrahydrofuran
T=25°C; Kumada Cross-Coupling; 24 h; Inert atmosphere;
参考文献
Sun, Yunqiang; Li, Xiaoyan; Sun, Hongjian
Dalton Transactions, 2014 , vol. 43, # 25 p. 9410 - 9413
反应条件
bis(carbene)-derived nickel(II)-pincer complex in tetrahydrofuran
T=20°C; Grignard coupling reaction; 48 h;
参考文献
Inamoto, Kiyofumi; Kuroda, Jun-Ichi; Sakamoto, Takao; Hiroya, Kou
Synthesis, 2007 , # 18 p. 2853 - 2861
反应条件
1.1: silicon tetrachloride / diethyl ether / -20 - 20 °C
2.1: 7.5 g / diethyl ether / 12 h / Heating
3.1: tetrabutylammonium fluoride trihydrate / tetrahydrofuran; H2O / 1 h / 20 °C
3.2: 89 percent / 2-dicyclohexylphosphino-2',4',6'-triisopropylbiphenyl / [(η3-C3H5)PdCl]2 / tetrahydrofuran; H2O / 3 h / 80 °C
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参考文献
Sahoo, Akhila K.; Oda, Takuro; Nakao, Yoshiaki; Hiyama, Tamejiro
Advanced Synthesis and Catalysis, 2004 , vol. 346, # 13-15 p. 1715 - 1727
反应条件
1: 4-methoxyphenyl magnesium bromide With N,N,N',N,-tetramethylethylenediamine; zinc(II) chloride in tetrahydrofuran
T=80°C; 0.25 h; microwave irradiation;
2: para-bromoacetophenone With bis-triphenylphosphine-palladium(II) chloride in tetrahydrofuran; N,N-dimethyl-formamide
T=80°C; Negishi cross-coupling; 0.0333333 h; microwave irradiation;
参考文献
Mutule, Ilga; Suna, Edgars
Tetrahedron, 2005 , vol. 61, # 47 p. 11168 - 11176
反应条件
1.1: 73 percent / diethyl ether / 0 - 20 °C
2.1: TBAF / tetrahydrofuran
2.2: 73 percent / TBAF; (t-Bu)3P / [(allyl)PdCl]2 / tetrahydrofuran / 1 h / Heating
View Scheme
参考文献
Denmark, Scott E.; Wu, Zhicai
Organic Letters, 1999 , vol. 1, # 9 p. 1495 - 1498
