3-甲基-CBS-氧硼啶合成路线 （共 731 条）
反应条件
1.1: tetrahydrofuran / 2 h / -30 - -25 °C / Inert atmosphere
1.2: Inert atmosphere
2.1: tetrahydrofuran / 2 h / 15 - 20 °C / Inert atmosphere
3.1: triethylsilane; trifluoroacetic acid / dichloromethane / 2 h / 0 - 20 °C
4.1: water; mercury dichloride; mercury(II) oxide / acetonitrile / 3 h / 70 °C
5.1: methanol; sodium tetrahydroborate / 1 h / 0 - 5 °C
6.1: triethylamine / dichloromethane / 0 - 20 °C
7.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / dichloromethane / 10 h / 20 °C
View Scheme
参考文献
Balasubramaniam, Sivaraman; Kommidi, Harikrishna; Aidhen, Indrapal Singh
Tetrahedron Letters, 2011 , vol. 52, # 21 p. 2683 - 2686
参考文献
Gollnick, Klaus; Schnatterer, Albert; Utschick, Gerald
Journal of Organic Chemistry, 1993 , vol. 58, # 22 p. 6049 - 6056
反应条件
1: in tetrahydrofuran
T=-20°C; 2 h;
2: With sodium tetrahydroborate; iron(II) chloride in tetrahydrofuran; ethanol
T=20°C; 2 h; Further stages.;
参考文献
Sapountzis, Ioannis; Knochel, Paul
Journal of the American Chemical Society, 2002 , vol. 124, # 32 p. 9390 - 9391
反应条件
1: diethyl ether / Heating
2: HCO2H / Heating
3: (i) O3, (ii) AcOOH
View Scheme
参考文献
Graham,S.H.; Williams,A.J.S.
Journal of the Chemical Society [Section] C: Organic, 1966 , p. 655 - 660
参考文献
Wohl
Bulletin de la Societe Chimique de France, 1938 , vol. <5>5, p. 460,465
反应条件
diethyl ether
Erhitzen des nach der Hydrolyse erhaltenen Reaktionsprodukts mit K2S2O7 unter Stickstoff auf 220grad;
参考文献
v. Wessely et al.
Monatshefte fuer Chemie, 1941 , vol. 73, p. 127,158
反应条件
1: toluene
2: acetic acid; aqueous HCl
3: 320 °C
View Scheme
参考文献
Buchta; Weidinger
Justus Liebigs Annalen der Chemie, 1953 , vol. 580, p. 109,113
反应条件
dilithium tetrachlorocuprate in tetrahydrofuran
12 h; Ambient temperature;
参考文献
Kadkhodayan, Miryam; Singleton, Terry; Heldrich, F. J.
Synthetic Communications, 1984 , vol. 14, # 8 p. 707 - 712
反应条件
dilithium tetrachlorocuprate in tetrahydrofuran
T=0 - 20°C; Grignard Reaction; 16 h;
参考文献
Yamaguchi, Yusuke; Okada, Yohei; Chiba, Kazuhiro
Journal of Organic Chemistry, 2013 , vol. 78, # 6 p. 2626 - 2638
反应条件
anhydrous iron chloride in tetrahydrofuran
T=20°C; 0.5 h; Inert atmosphere;
参考文献
Qian, Xin; Kozak, Christopher M.
Synlett, 2011 , # 6 p. 852 - 856
