3-甲基-CBS-氧硼啶合成路线 （共 731 条）
反应条件
PinP(O)H; [Pd(dibenzylideneacetone)2] in tetrahydrofuran; 1,4-dioxane
T=80°C; Kumada cross-coupling-reaction; 22 h;
参考文献
Ackermann, Lutz; Althammer, Andreas
Organic Letters, 2006 , vol. 8, # 16 p. 3457 - 3460
反应条件
triphenylphosphine; Pd bipyridyl anchored nanosized mesoporous silica MCM-41 in tetrahydrofuran
Kumada-Corriu reaction; 48 h; Heating;
参考文献
Tsai, Fu-Yu; Lin, Bo-Nan; Chen, Ming-Jie; Mou, Chung-Yuan; Liu, Shiuh-Tzung
Tetrahedron, 2007 , vol. 63, # 20 p. 4304 - 4309
反应条件
in tetrahydrofuran
T=20°C; Substitution; 15 h;
参考文献
Cardellicchio, Cosimo; Fracchiolla, Giuseppe; Naso, Francesco; Tortorella, Paolo; Holody, Wieslawa; Michal Pietrusiewicz
Tetrahedron Letters, 1999 , vol. 40, # 31 p. 5773 - 5776
反应条件
Multi-step reaction with 2 steps 1: diethyl ether2: HCl; CaCl2 / CH2Cl2 / -78 - 20 °C
参考文献
Van Pham, Thuy; McClelland, Robert A. Canadian Journal of Chemistry, 2001 , vol. 79, # 12 p. 1887 - 1897
反应条件
With diethyl ether; tellurium(II) bromide
参考文献
Lederer Chemische Berichte, 1920 , vol. 53, p. 713
反应条件
Multi-step reaction with 6 steps 1: 68 percent / diethyl ether; benzene / 1.) reflux, 3 h, 2.) RT, overnight2: 100 percent / methanesulfonic acid / 1.5 h / Ambient temperature3: 59 percent / zinc amalgam, conc. HCl / toluene; acetic acid / 27 h / Heating4: 1.) n-BuLi / 1.) ether, hexane, -30 deg C, 1 h, 2.) ether, hexane, from -30 deg C to RT5: 69 percent / conc,. H2SO4 / benzene / 20 h / Heating6: 96 percent / 10 N NaOH / pyridine / 3 h / Ambient temperature
参考文献
Rice, Joseph E.; Shih, Hsien-Cheng; Hussain, Nalband; LaVoie, Edmond J. Journal of Organic Chemistry, 1987 , vol. 52, # 5 p. 849 - 855
反应条件
Multi-step reaction with 2 steps 1: diethyl ether2: tetrachloromethane
参考文献
Supniewski, J.; Adams, R. J. Am. Chem. Soc,, 1926 , vol. 48, p. 507 - 517
反应条件
Multi-step reaction with 2 steps 1: anfangs in Aether, zuletzt in Benzol oder Toluol bei Siedetemperatur2: benzene; pyridine
参考文献
Hardegger; Redlich; Gal Helvetica Chimica Acta, 1945 , vol. 28, p. 628,633
反应条件
Multi-step reaction with 2 steps 1: benzene; diethyl ether / Erwaermen des nach der Hydrolyse erhaltenen Reaktionsproduks mit Aethanol2: benzene; diethyl ether / Erwaermen des nach der Hydrolyse erhaltenen Reaktionsprodukts mit Aethanol
参考文献
Baddar; El-Assal Journal of the Chemical Society, 1951 , p. 431
反应条件
Multi-step reaction with 5 steps 1: 79 percent / tetrahydrofuran / Ambient temperature2: H2SO4 / methanol / 4 h / Heating3: 4.5 N HCl / Heating4: H+ 5: LiBH4
参考文献
VanAtten, Mary K.; Ensinger, Carol L.; Chiu, Andrew T.; McCall, Dale E.; Nguyen, Tam T.; et al. Journal of Medicinal Chemistry, 1993 , vol. 36, # 25 p. 3985 - 3992
