N,N-二乙基-3,6-二氟氨甲酰苯甲酸合成路线 （共 7 条）
反应条件
1: 80 percent / diethylamine / diethyl ether 2: 1.) n-BuLi / 1.) THF, -78 deg C, 1 h, 2.) -65 deg C, 15 min View Scheme
参考文献
Crucius, Goeran; Kramer, Markus; Hanack, Michael; Ziegler, Thomas; Lyubimtsev, Alexey
Synlett, 2012 , vol. 23, # 17 p. 2501 - 2503,3
反应条件
n-butyllithium; carbon dioxide; water
参考文献
Crucius, Goeran; Kramer, Markus; Hanack, Michael; Ziegler, Thomas; Lyubimtsev, Alexey
Synlett, 2012 , vol. 23, # 17 p. 2501 - 2503,3
反应条件
n-butyllithium 1.) THF, -78 deg C, 1 h, 2.) -65 deg C, 15 min; Yield given. Multistep reaction;
参考文献
Krapcho, A. Paul; Getahun, Zelleka; Avery, Kenneth J.
Synthetic Communications, 1990 , vol. 20, # 14 p. 2139 - 2146
反应条件
1: H2SO4 / H2O / 1 h / Heating 2: 130 °C / 0.05 Torr View Scheme
参考文献
Crucius, Goeran; Kramer, Markus; Hanack, Michael; Ziegler, Thomas; Lyubimtsev, Alexey
Synlett, 2012 , vol. 23, # 17 p. 2501 - 2503,3
反应条件
sulfuric acid in water 1 h; Heating;
参考文献
Krapcho, A. Paul; Getahun, Zelleka; Avery, Kenneth J.
Synthetic Communications, 1990 , vol. 20, # 14 p. 2139 - 2146
反应条件
1: H2SO4 / H2O / 1 h / Heating 2: 130 °C / 0.05 Torr 3: 89 percent / AlCl3, NaCl / 1.5 h / 220 °C View Scheme
参考文献
Krapcho, A. Paul; Getahun, Zelleka; Avery, Kenneth J.
Synthetic Communications, 1990 , vol. 20, # 14 p. 2139 - 2146
反应条件
1: H2SO4 / H2O / 1 h / Heating
2: 130 °C / 0.05 Torr
3: 89 percent / AlCl3, NaCl / 1.5 h / 220 °C
4: 78 percent / pyridine / 48 h / Ambient temperature
View Scheme
参考文献
Krapcho, A. Paul; Getahun, Zelleka; Avery, Kenneth J.
Synthetic Communications, 1990 , vol. 20, # 14 p. 2139 - 2146
