(6R,7R)-6-(4-甲氧基苯基)-6,7-二氢吡咯并[2,1-d][1,5]苯并硫氮杂卓-7-醇合成路线 （共 3 条）
反应条件
1: 1.) sodium, ethanol / 1.) 15 min., 2.) THF, 60 deg C, 5h 2: 92 percent / NaOH / aq. ethanol / 5 h / Heating 3: 1.) PCl5, 2.) AlCl3 / 1.) CS2, 65 deg C, 6h, 2.) CH2Cl2, 55-60 deg C, 23h 4: 73 percent / LiAlH4 / tetrahydrofuran / 5 h / Heating View Scheme
参考文献
Nacci; Fiorini; Garofalo; Cagnotto
Farmaco, 1990 , vol. 45, # 5 p. 545 - 557
反应条件
1: 78 percent / N-bromosucchinimide / CCl4 / 25 h / Heating 2: 1.) sodium, ethanol / 1.) 15 min., 2.) THF, 60 deg C, 5h 3: 92 percent / NaOH / aq. ethanol / 5 h / Heating 4: 1.) PCl5, 2.) AlCl3 / 1.) CS2, 65 deg C, 6h, 2.) CH2Cl2, 55-60 deg C, 23h 5: 73 percent / LiAlH4 / tetrahydrofuran / 5 h / Heating View Scheme
参考文献
Nacci; Fiorini; Garofalo; Cagnotto
Farmaco, 1990 , vol. 45, # 5 p. 545 - 557
反应条件
1: 1.) sodium, ethanol / 1.) 15 min., 2.) THF, 60 deg C, 5h 2: 92 percent / NaOH / aq. ethanol / 5 h / Heating 3: 1.) PCl5, 2.) AlCl3 / 1.) CS2, 65 deg C, 6h, 2.) CH2Cl2, 55-60 deg C, 23h 4: 73 percent / LiAlH4 / tetrahydrofuran / 5 h / Heating View Scheme
参考文献
Nacci; Fiorini; Garofalo; Cagnotto
Farmaco, 1990 , vol. 45, # 5 p. 545 - 557
