2-(2-苯基乙炔基)吡啶合成路线 （共 60 条）
反应条件
tetrakis(triphenylphosphine) palladium(0); copper(l) chloride in N,N-dimethyl-formamide
T=80°C; cross-coupling; 16 h;
参考文献
Nishihara, Yasushi; Ikegashira, Kazutaka; Hirabayashi, Kazunori; Ando, Jun-Ichi; Mori, Atsunori; Hiyama, Tamejiro
Journal of Organic Chemistry, 2000 , vol. 65, # 6 p. 1780 - 1787
反应条件
1: 2-bromo-pyridine With n-butyllithium in diethyl ether; hexane
T=-78°C; 0.25 h; Inert atmosphere;
2: 1-(4'-methylphenylsulfonyl)-2-phenylethyne in diethyl ether; hexane
T=-78°C; 0.25 h; Inert atmosphere; regioselective reaction;
参考文献
Garcia Ruano, Jose Luis; Aleman, Jose; Marzo, Leyre; Alvarado, Cuauhtemoc; Tortosa, Mariola; Diaz-Tendero, Sergio; Fraile, Alberto
Chemistry - A European Journal, 2012 , vol. 18, # 27 p. 8414 - 8422
反应条件
1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride in dichloromethane
T=25°C; 24 h; Inert atmosphere;
参考文献
Wardrop, Duncan J.; Komenda, John P.
Organic Letters, 2012 , vol. 14, # 6 p. 1548 - 1551
反应条件
B-OMe-9-borabicyclo[3.3.1]nonane; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride in tetrahydrofuran
Heating;
参考文献
Fuerstner, Alois; Seidel, Guenter
Tetrahedron, 1995 , vol. 51, # 41 p. 11165 - 11176
反应条件
copper(l) iodide; cesium fluoride in toluene; acetonitrile
T=150°C; 0.5 h; Inert atmosphereMicrowave irradiation;
参考文献
Akubathini, Shashidhar Kumar; Biehl, Ed
Tetrahedron Letters, 2009 , vol. 50, # 16 p. 1809 - 1811
反应条件
air; sodium acetate; Pd on porous glass in N,N-dimethyl acetamide
T=140°C; 100 h; Title compound not separated from byproducts;
参考文献
Li, Jintong; Mau, Albert W.-H.; Strauss, Christopher R.
Chemical Communications, 1997 , # 14 p. 1275 - 1276
反应条件
1: With n-butyllithium in tetrahydrofuran; hexane
T=-78°C;
2: With diethyl chlorophosphate in tetrahydrofuran; hexane
T=20°C;
3: With lithium hexamethyldisilazane in tetrahydrofuran; hexane
T=-78 - 20°C;
参考文献
Orita, Akihiro; Nakano, Takehiko; Yokoyama, Taisaku; Babu, Govindarajulu; Otera, Junzo
Chemistry Letters, 2004 , vol. 33, # 10 art. no. CL-040868, p. 1298 - 1299
反应条件
1: With n-butyllithium in tetrahydrofuran; hexane
T=-78°C;
2: With diethyl chlorophosphate in tetrahydrofuran; hexane
T=20°C;
3: With lithium hexamethyldisilazane in tetrahydrofuran; hexane
T=-78 - 20°C;
参考文献
Orita, Akihiro; Nakano, Takehiko; Yokoyama, Taisaku; Babu, Govindarajulu; Otera, Junzo
Chemistry Letters, 2004 , vol. 33, # 10 art. no. CL-040868, p. 1298 - 1299
反应条件
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; copper(l) iodide; triethylamine in tetrahydrofuran
T=100°C; Sonogashira-type coupling; 2 h; Microwave irradiation;
参考文献
Shook, Brian C.; Chakravarty, Devraj; Jackson, Paul F.
Tetrahedron Letters, 2009 , vol. 50, # 9 p. 1013 - 1015
反应条件
bis-triphenylphosphine-palladium(II) chloride; oxygen in 1,4-dioxane
T=80°C; Sonogashira type coupling; 18 h;
参考文献
Wang, Xuan; Qin, Weiwei; Kakusawa, Naoki; Yasuike, Shuji; Kurita, Jyoji
Tetrahedron Letters, 2009 , vol. 50, # 46 p. 6293 - 6297
