1,3-双(2,6-二异丙苯基)-2,2-二氟-2,3-二氢-1H-咪唑合成路线 （共 5 条）
反应条件
cesium fluoride in acetonitrile T=23 - 60°C; Inert atmosphere;
参考文献
PRESIDENT AND FELLOWS OF HARVARD COLLEGE; RITTER, Tobias; TANG, Pingping
Patent: WO2012/142162 A2, 2012 ;
Location in patent: Page/Page column 21 ;
反应条件
1.1: acetic acid / methanol; water / 10.25 h / 23 - 50 °C / Inert atmosphere 2.1: chloro-trimethyl-silane / ethyl acetate / 2.75 h / 70 °C / Inert atmosphere 3.1: potassium tert-butylate / tetrahydrofuran / 4 h / 23 °C / Inert atmosphere 3.2: -40 - 23 °C / Inert atmosphere 4.1: cesium fluoride / acetonitrile / 23 - 60 °C / Inert atmosphere View Scheme
参考文献
Tang, Pingping; Wang, Weike; Ritter, Tobias
Journal of the American Chemical Society, 2011 , vol. 133, # 30 p. 11482 - 11484
反应条件
1.1: chloro-trimethyl-silane / ethyl acetate / 2.75 h / 70 °C / Inert atmosphere 2.1: potassium tert-butylate / tetrahydrofuran / 4 h / 23 °C / Inert atmosphere 2.2: -40 - 23 °C / Inert atmosphere 3.1: cesium fluoride / acetonitrile / 23 - 60 °C / Inert atmosphere View Scheme
参考文献
Tang, Pingping; Wang, Weike; Ritter, Tobias
Journal of the American Chemical Society, 2011 , vol. 133, # 30 p. 11482 - 11484
反应条件
1.1: potassium tert-butylate / tetrahydrofuran / 4 h / 23 °C / Inert atmosphere 1.2: -40 - 23 °C / Inert atmosphere 2.1: cesium fluoride / acetonitrile / 23 - 60 °C / Inert atmosphere View Scheme
参考文献
Tang, Pingping; Wang, Weike; Ritter, Tobias
Journal of the American Chemical Society, 2011 , vol. 133, # 30 p. 11482 - 11484
反应条件
1: 1,2,2-trichloro-1,1,2-trichloro-ethane / tetrahydrofuran / 24 h / -40 - 23 °C 2: cesium fluoride / acetonitrile / 24 h / 60 °C View Scheme
参考文献
PRESIDENT AND FELLOWS OF HARVARD COLLEGE; RITTER, Tobias; TANG, Pingping
Patent: WO2012/142162 A2, 2012 ;
